ID | 62362 |
フルテキストURL | |
著者 |
Miyoshi, Toru
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
Ito, Hiroshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
Shirai, Kohji
Department of Internal Medicine, Mihama Hospital
Horinaka, Shigeo
Department of Cardiovascular Medicine, Dokkyo Medical University
Higaki, Jitsuo
Department of Cardiology, South Matsuyama Hospital
Yamamura, Shigeo
Faculty of Pharmaceutical Sciences, Josai International University
Saiki, Atsuhito
Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Sakura-City
Takahashi, Mao
Division of Cardiovascular Medicine (Sakura), Department of Internal Medicine, Faculty of Medicine, Toho University
Masaki, Mitsuru
Division of Clinical Laboratory Medicine, Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine
Okura, Takafumi
Department of Cardiology, Yawatahama City General Hospital
Kotani, Kazuhiko
Division of Community and Family Medicine, Jichi Medical University
Kubozono, Takuro
Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University
Yoshioka, Ryo
Department of Cardiovascular Medicine, The Sakakibara Heart Institute of Okayama
Kihara, Hajime
Department of Internal Medicine, Kihara Cardiovascular Clinic
Hasegawa, Koji
Division of Translational Research
Satoh-Asahara, Noriko
Department of Endocrinology, Metabolism, and Hypertension Research
Orimo, Hajime
Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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抄録 | BACKGROUND: Arterial stiffness is an important predictor of cardiovascular events; however, indexes for measuring arterial stiffness have not been widely incorporated into routine clinical practice. This study aimed to determine whether the cardio-ankle vascular index (CAVI), based on the blood pressure-independent stiffness parameter beta and reflecting arterial stiffness from the origin of the ascending aorta, is a good predictor of cardiovascular events in patients with cardiovascular disease risk factors in a large prospective cohort.
METHODS AND RESULTS: This multicenter prospective cohort study, commencing in May 2013, with a 5-year follow-up period, included patients (aged 40-74 years) with cardiovascular disease risks. The primary outcome was the composite of cardiovascular death, nonfatal stroke, or nonfatal myocardial infarction. Among 2932 included patients, 2001 (68.3%) were men; the mean (SD) age at diagnosis was 63 (8) years. During the median follow-up of 4.9 years, 82 participants experienced primary outcomes. The CAVI predicted the primary outcome (hazard ratio, 1.38; 95% CI, 1.16-1.65; P<0.001). In terms of event subtypes, the CAVI was associated with cardiovascular death and stroke but not with myocardial infarction. When the CAVI was incorporated into a model with known cardiovascular disease risks for predicting cardiovascular events, the global chi(2) value increased from 33.8 to 45.2 (P<0.001), and the net reclassification index was 0.254 (P=0.024). CONCLUSIONS: This large cohort study demonstrated that the CAVI predicted cardiovascular events. |
キーワード | arterial stiffness
blood pressure
cardiovascular events
pulse-wave velocity
risk factor
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発行日 | 2021-08-17
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出版物タイトル |
Journal of The American Heart ASSOCIATION
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巻 | 10巻
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号 | 16号
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出版者 | Wiley
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開始ページ | e020103
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ISSN | 2047-9980
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2021 The Authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1161/JAHA.120.020103
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ライセンス | https://creativecommons.org/licenses/by-nc-nd/4.0/
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助成機関名 |
Japan Vascular Disease Research Foundation
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オープンアクセス(出版社) |
OA
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