ID | 32805 |
JaLCDOI | |
フルテキストURL | |
著者 |
Matsuka, Yoko
Okayama University
Suganuma, Narufumi
Okayama Univresity
Imai, Kaori
Okayama University
Taketa, Kazuhisa
Okayama University
Kira, Shohei
Okayama University
|
抄録 | We studied the association of gamma-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking. |
キーワード | gamma-glutamyltransferase(GGT)
daily alcohol consumption
good responder and poor responder
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2003-08
|
巻 | 57巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 171
|
終了ページ | 178
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |