ID | 53521 |
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著者 |
Ishii, Hiroko
Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
Kamikawa, Shigeshi
Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
Hirohata, Satoshi
Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
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Mizutani, Akifumi
Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
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Abe, Koji
Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
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Seno, Masaharu
Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
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Oohashi, Toshitaka
Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
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抄録 | Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
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キーワード | ECP
reactive oxygen species
Akt
ERK
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Amo Type | Original Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2015-06
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巻 | 69巻
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号 | 3号
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出版者 | Okayama University Medical School
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開始ページ | 145
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終了ページ | 153
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2015 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |