Takao, Miyuki Division of Infection Control and Prevention, Osaka University Hospital
Yoshioka, Nori Division of Infection Control and Prevention, Osaka University Hospital
Hagiya, Hideharu Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Deguchi, Matsuo Division of Infection Control and Prevention, Osaka University Hospital
Kagita, Masanori Division of Infection Control and Prevention, Osaka University Hospital
Tsukamoto, Hiroko Laboratory for Clinical Investigation, Osaka University Hospital
Hidaka, Yoh Laboratory for Clinical Investigation, Osaka University Hospital
Tomono, Kazunori Division of Infection Control and Prevention, Osaka University Hospital
Tobe, Toru Department of Biomedical Informatics, Osaka University Graduate School of Medicine
Background Cytomegalovirus (CMV) are ubiquitously distributed worldwide, causing a wide range of clinical manifestations from congenital infection to a life-threatening disease in immunocompromised individuals. CMV can be transmitted via human-to-human contact through body fluids; however, the risk of CMV infection among healthcare workers (HCWs) has not been fully evaluated. Aim This study aimed to assess the risk of CMV infection among HCWs through daily medical practices. Methods Serum samples from HCWs at Osaka University Hospital (Japan) were analysed. Initially, we compared CMV IgG seropositivity among HCWs (medical doctors, nurses, and others) in 2017, which was examined after 1 year to evaluate seroconversion rates among those with seronegative results. Then, we examined CMV seroconversion rates in HCWs who were exposed to blood and body fluids. Findings We analysed 1153 samples of HCWs (386 medical doctors, 468 nurses, and 299 others), of which CMV seropositivity rates were not significantly different (68.9%, 70.3%, and 70.9%, respectively). Of these, 63.9% (221/346) of CMV seronegative HCWs were followed after 1 year, with CMV seroconversion rates of 3.2% (7/221). Among 72 HCWs who tested negative for CMV IgG when exposed to blood and body fluids, the CMV seroconversion rate was 2.8% (2/72). The CMV seroconversion rates between the two situations were not significantly different. Conclusion Our study indicated that CMV infection through daily patient care seems quite rare. Further well-designed studies with a large sample size are warranted to verify our finding.
Blood and body fluid exposure
This fulltext is available in March 2021.
Journal of Infection and Chemotherapy
© 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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