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ID 58737
著者
Takao, Miyuki Division of Infection Control and Prevention, Osaka University Hospital
Yoshioka, Nori Division of Infection Control and Prevention, Osaka University Hospital
Hagiya, Hideharu Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Deguchi, Matsuo Division of Infection Control and Prevention, Osaka University Hospital
Kagita, Masanori Division of Infection Control and Prevention, Osaka University Hospital
Tsukamoto, Hiroko Laboratory for Clinical Investigation, Osaka University Hospital
Hidaka, Yoh Laboratory for Clinical Investigation, Osaka University Hospital
Tomono, Kazunori Division of Infection Control and Prevention, Osaka University Hospital
Tobe, Toru Department of Biomedical Informatics, Osaka University Graduate School of Medicine
抄録
Background
Cytomegalovirus (CMV) are ubiquitously distributed worldwide, causing a wide range of clinical manifestations from congenital infection to a life-threatening disease in immunocompromised individuals. CMV can be transmitted via human-to-human contact through body fluids; however, the risk of CMV infection among healthcare workers (HCWs) has not been fully evaluated.
Aim
This study aimed to assess the risk of CMV infection among HCWs through daily medical practices.
Methods
Serum samples from HCWs at Osaka University Hospital (Japan) were analysed. Initially, we compared CMV IgG seropositivity among HCWs (medical doctors, nurses, and others) in 2017, which was examined after 1 year to evaluate seroconversion rates among those with seronegative results. Then, we examined CMV seroconversion rates in HCWs who were exposed to blood and body fluids.
Findings
We analysed 1153 samples of HCWs (386 medical doctors, 468 nurses, and 299 others), of which CMV seropositivity rates were not significantly different (68.9%, 70.3%, and 70.9%, respectively). Of these, 63.9% (221/346) of CMV seronegative HCWs were followed after 1 year, with CMV seroconversion rates of 3.2% (7/221). Among 72 HCWs who tested negative for CMV IgG when exposed to blood and body fluids, the CMV seroconversion rate was 2.8% (2/72). The CMV seroconversion rates between the two situations were not significantly different.
Conclusion
Our study indicated that CMV infection through daily patient care seems quite rare. Further well-designed studies with a large sample size are warranted to verify our finding.
キーワード
Blood and body fluid exposure
Cytomegalovirus
Healthcare workers
Occupational infection
Seroconversion
備考
This fulltext is available in March 2021.
発行日
2020-03-10
出版物タイトル
Journal of Infection and Chemotherapy
26巻
7号
出版者
Elsevier
開始ページ
681
終了ページ
684
ISSN
1341-321X
NCID
AA11057978
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1016/j.jiac.2020.02.011
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/