ID | 58703 |
フルテキストURL | |
著者 |
Kashima, Soki
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Maeda, Takuya
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Masuda, Kyoko
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Nagano, Seiji
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Inoue, Takamitsu
Department of Urology, Akita University Graduate School of Medicine
Takeda, Masashi
Department of Urology, Kyoto University Graduate School of Medicine
Kono, Yuka
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Kobayashi, Takashi
Department of Urology, Kyoto University Graduate School of Medicine
Saito, Shigeyoshi
Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University
Higuchi, Takahiro
Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
ORCID
Kaken ID
publons
researchmap
Ichise, Hiroshi
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Kobayashi, Yuka
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Iwaisako, Keiko
Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University
Terada, Koji
Department of Biochemistry and Molecular Biology, Shiga University of Medical School
Agata, Yasutoshi
Department of Biochemistry and Molecular Biology, Shiga University of Medical School
Numakura, Kazuyuki
Department of Urology, Akita University Graduate School of Medicine
Saito, Mitsuru
Department of Urology, Akita University Graduate School of Medicine
Narita, Shintaro
Department of Urology, Akita University Graduate School of Medicine
Yasukawa, Masaki
Department of Hematology, Clinical Immunology and Infectious Diseases, Graduate School of Medicine, Ehime University
Ogawa, Osamu
Department of Urology, Kyoto University Graduate School of Medicine
Habuchi, Tomonori
Department of Urology, Akita University Graduate School of Medicine
Kawamoto, Hiroshi
Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
|
抄録 | Current adoptive T cell therapies conducted in an autologous setting are costly, time consuming, and depend on the quality of the patient's T cells. To address these issues, we developed a strategy in which cytotoxic T lymphocytes (CTLs) are regenerated from iPSCs that were originally derived from T cells and succeeded in regenerating CTLs specific for the WT1 antigen, which exhibited therapeutic efficacy in a xenograft model of leukemia. In this study, we extended our strategy to solid tumors. The regenerated WT1-specific CTLs had a strong therapeutic effect in orthotopic xenograft model using a renal cell carcinoma (RCC) cell line. To make our method more generally applicable, we developed an allogeneic approach by transducing HLA-haplotype homozygous iPSCs with WT1-specific TCR α/β genes that had been tested clinically. The regenerated CTLs antigen-specifically suppressed tumor growth in a patient-derived xenograft model of RCC, demonstrating the feasibility of our strategy against solid tumors.
|
キーワード | Cancer
Cellular Therapy
Immunological Methods
|
発行日 | 2020-04-24
|
出版物タイトル |
iScience
|
巻 | 23巻
|
号 | 4号
|
出版者 | Cell Press
|
開始ページ | 100998
|
ISSN | 25890042
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © 2020 The Author(s).
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1016/j.isci.2020.100998
|
ライセンス | http://creativecommons.org/licenses/by/4.0/
|
Citation | Kashima S, Maeda T, Masuda K, et al. Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model. iScience. 2020;23(4):100998. doi:10.1016/j.isci.2020.100998
|
助成機関名 |
日本学術振興会
|
助成番号 | 18J10676
|
オープンアクセス(出版社) |
OA
|
オープンアーカイブ(出版社) |
非OpenArchive
|