ID | 49928 |
フルテキストURL | |
著者 |
Nakatsuka, Atsuko
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
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Wada, Jun
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
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Iseda, Izumi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Teshigawara, Sanae
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
Higashio, Kanji
Metabolome Pharmaceut Inc
Murakami, Kazutoshi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
ORCID
Kaken ID
publons
Kanzaki, Motoko
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Inoue, Kentaro
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Terami, Takahiro
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Katayama, Akihiro
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Hida, Kazuyuki
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci, Okayama
Eguchi, Jun
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
researchmap
Horiguchi, Chikage Sato
Okayama Univ, Dept Diabet Nephropathy, Grad Sch Med Dent & Pharmaceut Sci
Ogawa, Daisuke
Okayama Univ, Dept Diabet Nephropathy, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
Matsuki, Yasushi
Dainippon Sumitomo Pharma, Genom Sci Labs
Hiramatsu, Ryuji
Dainippon Sumitomo Pharma, Genom Sci Labs
Yagita, Hideo
Juntendo Univ, Sch Med, Dept Immunol
Kakuta, Shigeru
Univ Tokyo, Inst Med Sci, Ctr Expt Med & Syst Biol
Iwakura, Yoichiro
Univ Tokyo, Inst Med Sci, Ctr Expt Med & Syst Biol
Makino, Hirofumi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
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抄録 | It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral adipose tissue-derived serine protease inhibitor (vaspin) binds to cell-surface 78-kDa glucose-regulated protein (GRP78), which is recruited from ER to plasma membrane under ER stress. Vaspin transgenic mice were protected from diet-induced obesity, glucose intolerance, and hepatic steatosis, while vaspin-deficient mice developed glucose intolerance associated with upregulation of ER stress markers. With tandem affinity tag purification using HepG2 cells, we identified GRP78 as an interacting molecule. The complex formation of vaspin, GRP78, and murine tumor cell DnaJ-like protein 1 (MTJ-1) (DnaJ homolog, subfamily C, member 1) on plasma membrane was confirmed by cell-surface labeling with biotin and immunoprecipitation in liver tissues and H-4-II-E-C3 cells. The addition of recombinant human vaspin in the cultured H-4-II-E-C3 cells also increased the phosphorylation of Akt and AMP-activated protein kinase (AMPK) in a dose-dependent manner, and anti-GRP78 antibodies completely abrogated the vaspin-induced upregulation of pAkt and pAMPK Vaspin is a novel ligand for cell-surface GRP78/MTJ-1 complex, and its subsequent signals exert beneficial effects on ER stress-induced metabolic dysfunctions. Diabetes 61:2823-2832, 2012
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発行日 | 2012-11
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出版物タイトル |
Diabetes
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巻 | 61巻
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号 | 11号
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開始ページ | 2823
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終了ページ | 2832
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ISSN | 0012-1797
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.2337/db12-0232
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/49735
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言語 |
英語
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |