| ID | 67497 |
| 著者 |
Tokushige, Keisuke
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Abe, Takumi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
researchmap
|
| 抄録 | Unprecedented tert-BuOK-mediated one carbon deletion of indoline hemiaminals has been achieved. This novel protocol provides an efficient synthetic tool for the construction of 2-aminobenzyl compounds with high chemoselectivity. In addition, functionalized 2-aminobenzyl compounds are difficult to make, for which few limited means of access currently exist. The key to success is the use of in situ generated Heyns rearrangement products (α-amino carbonyl compounds) as precursors for formal one carbon deletion.
|
| 備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.4c00884.
This fulltext file will be available in Jun. 2025.
|
| 発行日 | 2024-07-01
|
| 出版物タイトル |
The Journal of Organic Chemistry
|
| 巻 | 89巻
|
| 号 | 14号
|
| 出版者 | American Chemical Society (ACS)
|
| 開始ページ | 10349
|
| 終了ページ | 10354
|
| ISSN | 0022-3263
|
| NCID | AA00704100
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| OAI-PMH Set |
岡山大学
|
| 著作権者 | © 2024 American Chemical Society
|
| 論文のバージョン | author
|
| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| 関連URL | isVersionOf https://doi.org/10.1021/acs.joc.4c00884
|
| 助成機関名 |
Japan Society for the Promotion of Science
Japan Science and Technology Agency
|
| 助成番号 | 22K06503
JPMJSP2126
|
