ID | 32678 |
JaLCDOI | |
フルテキストURL | |
著者 |
Sakagami, Kenichi
Okayama University
Shiozaki, Shigehiro
Okayama University
Fujiwara, Takuzo
Okayama University
Haisa, Minoru
Okayama University
Niguma, Takefumi
Okayama University
Kusaka, Satoshi
Okayama University
Uda, Masashi
Okayama University
Matsuno, Tsuyoshi
Okayama University
Takasu, Shinji
Okayama University
Yerdel, Mehmet Ali
Okayama University
Matsuoka, Junji
Okayama University
Tanaka, Shinichiro
Okayama University
Orita, Kunzo
Okayama University
|
抄録 | One-hundred-nine HLA-haploidentical living related renal transplants have been retrospectively analysed to compare the effect of donor-specific blood transfusion (DST) and different immunosuppressive regimens on graft survival and acute rejection. The recipients were divided into four groups according to the immunosuppressive therapy. Group 1 (n = 44): conventional therapy with posttransplant azathioprine (AZP) + methylprednisolone (MP). Group 2 (n = 25): pretransplant DST + posttransplant AZP + MP. Group 3 (n = 12): triple-drug therapy with posttransplant AZP + MP + cyclosporine (CS). Group 4 (n = 25): pretransplant DST + posttransplant AZP + MP + CS. The five-year actuarial survival rates for groups 1, 2, 3 and 4 were 48%, 73%, 79%, and 89%, respectively. The graft survival rate in group 3 was significantly (p less than 0.01) better than that in group 1. The transfusion effect was reduced, and appears as a 10% improvement in the graft survival in the cyclosporin era compared with a 25% improvement at pre-cyclosporin era. Furthermore, the incidence of the first rejection episode was decreased in recipients that received DST. The present study revealed that DST, as pretransplant conditioning has a definite impact on rejection-free long-term graft survival in HLA-haploidentical living-related kidney recipients and the most favorable outcome in such patients could be achieved by DST pretreatment in conjunction with posttransplant triple-drug therapy including cyclosporine. |
キーワード | living-related kindney transplantation
donor-specific blood transfusion (DST)
cyclosporine
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1992-02
|
巻 | 46巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 1
|
終了ページ | 5
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |