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ID 54805
JaLCDOI
フルテキストURL
著者
Yamashita, Miho Department of Pediatrics, Okayama University Hospital
Hasegawa, Kosei Department of Pediatrics, Okayama University Hospital ORCID Kaken ID researchmap
Higuchi, Yousuke Department of Pediatrics, Okayama University Hospital
Miyai, Takayuki Department of Pediatrics, Okayama University Hospital
Okada, Ayumi Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tanaka, Hiroyuki Department of Pediatrics, Okayama Saiseikai General Hospital
Tsukahara, Hirokazu Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
抄録
The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p<0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p<0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
キーワード
bone resorption marker
bone turnover
bone mass
Amo Type
Original Article
発行日
2016-12
出版物タイトル
Acta Medica Okayama
70巻
6号
出版者
Okayama University Medical School
開始ページ
435
終了ページ
439
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID