ID | 48566 |
JaLCDOI | |
フルテキストURL | |
著者 |
Sasaki, Takanori
Departments of Radiology, Okayama University Graduate School of Medicine
Kaken ID
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Kuroda, Masahiro
Radiological Technology, Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
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Katashima, Kazunori
Departments of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine
Ashida, Masakazu
Departments of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine
Matsuzaki, Hidenobu
Departments of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine
Kaken ID
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Asaumi, Junichi
Departments of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine
Kaken ID
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Murakami, Jun
Departments of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine
Kaken ID
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Ohno, Seiichiro
Central Division of Radiology, Okayama University Hospital
Kato, Hirokazu
Radiological Technology, Graduate School of Health Sciences, Okayama University
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抄録 | The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated
using bio-phantoms. In these bio-phantoms, Ramos cells (a human Burkittセs lymphoma cell line) were encapsulated in gellan gum. The ADC values decreased linearly with the increase in cell density, and declined steeply when the extracellular space became less than 4 μm. The analysis of ADC values after destruction of the cellular membrane by sonication indicated that approximately 65% of the ADC values of normal cells originate from the cell structures made of membranes and that the remaining 35% originate from intracellular components. Microparticles, defined as particles smaller than the normal cells, increased in number after rituximab treatments, migrated to the extracellular space and significantly decreased the ADC values of bio-phantoms during apoptosis. An in vitro study using bio-phantoms was conducted to quantitatively clarify the roles of cellular factors and of extracellular space in determining the ADC values yielded by tumor cells and the mechanism by which apoptosis changes those values.
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キーワード | apparent diffusion coefficient value
cell density
extracellular space
bio-phantom
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Amo Type | Original Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2012-06
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巻 | 66巻
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号 | 3号
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出版者 | Okayama University Medical School
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開始ページ | 263
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終了ページ | 270
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2012 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |