ID | 52813 |
フルテキストURL | |
著者 |
Sonoi, Norihiro
Okayama Univ, Dept Pathophysiol Periodontal Sci, Grad Sch Med Dent & Pharmaceut Sci
Maeda, Hiroshi
Okayama Univ, Dept Pathophysiol Periodontal Sci, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
publons
Ichimura, Koichi
Okayama Univ, Dept Pathol, Grad Sch Med Dent & Pharmaceut Sci
Yoshino, Tadashi
Okayama Univ, Dept Pathol, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
publons
researchmap
Aoyama, Kazutoshi
Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Fujii, Nobuharu
Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
publons
researchmap
Maeda, Yoshinobu
Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
researchmap
Tanimoto, Mitsune
Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
publons
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Logan, Richard
Univ Adelaide, Fac Hlth Sci, Sch Dent
Raber-Durlacher, Judith
Acad Ctr Dent Amsterdam, Dept Periodontol
Takashiba, Shogo
Okayama Univ, Dept Pathophysiol Periodontal Sci, Grad Sch Med Dent & Pharmaceut Sci
ORCID
Kaken ID
publons
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抄録 | Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.
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キーワード | Gingival enlargement
Acute myelomonocytic leukemia
Pathogenesis
Histology
Immunohistochemistry
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備考 | The final publication is available at link.springer.com
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発行日 | 2012-07
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出版物タイトル |
Odontology
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巻 | 100巻
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号 | 2号
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開始ページ | 254
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終了ページ | 257
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ISSN | 1618-1247
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | © The Society of The Nippon Dental University 2011
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |