ID | 30833 |
JaLCDOI | |
フルテキストURL | |
著者 |
Koide, Noriko
Okayama University
Tomoda, Jun
Okayama University
Hayashi, Hideo
Okayama University
Hatase, Osamu
Okayama University
Oda, Takuzo
Okayama University
|
抄録 | The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more than -5.8 Kcal/mol to the free energy of binding. This value was consistent with the free energy change expected from the transfer of n-butane from an aqueous environment to liquid n-butane. The observed contribution was explained, in terms of the hydrophobic interaction of the isobutyl group with the antigen binding site of the antibody molecule. These results were also compared with other hapten-antibody systems. |
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1977-10
|
巻 | 31巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 289
|
終了ページ | 294
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
NAID |