ID | 31596 |
JaLCDOI | |
フルテキストURL | |
著者 |
Miyamoto, Osamu
Kagawa Medical School
Itano, Toshifumi
Kagawa Medical School
Fujisawa, Mutsuo
Kagawa Medical School
Tokuda, Masaaki
Kagawa Medical School
Nagao, Seigo
Kagawa Medical School
Hatase, Osamu
Kagawa Medical School
|
抄録 | Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) were administered into the rat brain following unilateral fimbria-fornix transection. Both bFGF and NGF stimulated the sprouting of acetylcholinesterase (AChE) positive fibers in the hippocampus on the lesioned side. Furthermore, a small number of AChE-positive fibers were regenerated even when only the vehicle was administered. Rats treated with NGF as well as control group had only thin fibers, whereas those treated with bFGF had not only thin fibers but also thick fibers. These results indicate that intrinsic NGF is released and acts on damaged neurons directly, while bFGF acts them on directly and/or indirectly after brain injury. |
キーワード | bFGF
NGF
regeneration
acetylcholinesterase positive fibers
sprouting
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1993-06
|
巻 | 47巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 139
|
終了ページ | 144
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |