著者 座間味 義人| 高取 真吾| 合田 光寛| 小山 敏広| 岩谷 有希子| Jin, Xin| Takada-Doi, Shima| 川﨑 博己|
発行日 2008-11-01
出版物タイトル Biological & Pharmaceutical Bulletin
31巻
11号
資料タイプ 学術雑誌論文
著者 座間味 義人| 高取 真吾| 小山 敏広| 合田 光寛| 岩谷 有希子| 土井 志真| 川﨑 博己|
発行日 2007-12-01
出版物タイトル 藥學雜誌
127巻
12号
資料タイプ 学術雑誌論文
著者 座間味 義人| 高取 真吾| 岩谷 有希子| 山脇 康佑| 宮下 智子| 藪前 奈々| 高山 房子| 見尾 光庸| 川﨑 博己|
発行日 2008-03-01
出版物タイトル 藥學雜誌
128巻
3号
資料タイプ 学術雑誌論文
著者 座間味 義人| 藤原 弘喜| 細田 美穂| 日野 隼人| 平井 和浩| 岡本 和明| 金 鑫| 高取 真吾| 高木 志真| 川﨑 博己|
発行日 2010-06-01
出版物タイトル 藥學雜誌
130巻
6号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/40129
フルテキストURL 64_4_219.pdf
著者 Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa|
抄録 We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
キーワード ACTH imipramine lithium proliferation Ki-67
Amo Type Original Article
発行日 2010-08
出版物タイトル Acta Medica Okayama
64巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 223
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20802538
Web of Sience KeyUT 000281384400002
著者 Kurosaki, Yuji| Tagawa, Masahiro| Omoto, Akiho| Suito, Hiroshi| Komori, Yukiko| Kawasaki, Hiromu| Aiba, Tetsuya|
発行日 2008-05-22
出版物タイトル International Journal of Pharmaceutics
343巻
資料タイプ 学術雑誌論文
著者 Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka|
発行日 2008-05-20
出版物タイトル Pharmacology Biochemistry and Behavior
89巻
3号
資料タイプ 学術雑誌論文
著者 Hobara, Narumi| Goda, Mitsuhiro| Yoshida, Namika| Takatori, Shingo| Kitamura, Yoshihisa| Mio, Mitsunobu| Kawasaki, Hiromu|
発行日 2008-05-28
出版物タイトル Neuroscience
150巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32879
フルテキストURL fulltext.pdf
著者 Umeda, Yuichi| Amano, Manabu| Suemaru, Katsuya| Yamaguchi, Takumi| Kitamura, Yoshihisa| Gomita, Yutaka| Kawasaki, Hiromu| Araki, Hiroaki|
抄録 <p>Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-HT2A receptor-mediated wet-dog shake responses in rats treated with adrenocorticotropic hormone (ACTH), dexamethasone and streptozotocin. ACTH (100 &#956;g/rat per day, s.c.), dexamethasone (1 mg/kg per day, s.c.) and streptozotocin (60 mg/kg, i.p.) produced significant hyperglycemia at 14 days after the start of these treatments, and the hyperglycemia was most pronounced in the streptozotocin-treated rats. The wet-dog shake responses induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2A receptor agonist, were significantly enhanced at 14 days after repeated treatment with ACTH and dexamethasone. However, streptozotocin-induced diabetes had no effect on the wet-dog shake responses. The results of the present study suggest that hyperglycemia is not strongly associated with the enhanced susceptibility of 5-HT2A receptors under the condition of hyperactivity of the HPA axis.</p>
キーワード hyperglycemia ACTH dexamethasone streptozotocin 5-HT2A receptor
Amo Type Original Article
発行日 2007-12
出版物タイトル Acta Medica Okayama
61巻
6号
出版者 Okayama University Medical School
開始ページ 311
終了ページ 317
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18183075
Web of Sience KeyUT 000251943800001
JaLCDOI 10.18926/AMO/32870
フルテキストURL fulltext.pdf
著者 Amano, Manabu| Suemaru, Katsuya| Cui, Ranji| Umeda, Yuichi| Li, Bingjin| Gomita, Yutaka| Kawasaki, Hiromu| Araki, Hiroaki|
抄録 Several epidemiological and clinical studies have indicated that the prevalence of psychiatric disorders is higher in diabetic patients than in the general population. In the present studies, we examined the behavioral changes in streptozotocin-induced diabetic rats, and investigated the effects of physical and psychological stress on the hippocampal BDNF levels and on the serotonin 2A (5-HT2A) receptor-mediated wet-dog shake responses. The streptozotocin (60 mg/kg, i.p.)-induced diabetes had no significant effects on the immobility time in the forced swim test or on locomotor activity in the open-field test. Moreover, there was no significant difference in the wet-dog shake responses induced by DOI, a 5-HT2A receptor agonist, between nondiabetic and diabetic rats. Five-day exposure to physical (electric footshock) and psychological (non-footshock) stress had no signifi cant effect on the hippocampal BDNF level in diabetic or nondiabetic rats. The 2 types of stress had no significant effect on the DOI-induced wet-dog shake responses in nondiabetic rats. In diabetic rats, the repeated exposure to physical stress markedly increased the DOI-induced wet-dog shake responses, but the repeated exposure to psychological stress had no effect. These results suggest that exposure to physical stress augmented the susceptibility to the wet-dog shake responses to 5-HT2A receptor stimulation in streptozotocin-induced diabetic rats.
キーワード streptozotocin physical stress psychological stress 5-HT2A receptor wet-dog shake
Amo Type Original Article
発行日 2007-08
出版物タイトル Acta Medica Okayama
61巻
4号
出版者 Okayama University Medical School
開始ページ 205
終了ページ 212
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17726509
Web of Sience KeyUT 000248957100004
JaLCDOI 10.18926/AMO/32306
フルテキストURL fulltext.pdf
著者 Hashimoto, Yasuhiko| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>The influences of emotional changes induced by being exposed to a new environment on the pharmacokinetics of plasma drug concentration were studied in male Wistar rats. Transfer from a familiar home cage to a new home cage was considered to induce psychological (non-physical) emotional changes. First, nicorandil and zonisamide, drugs that act on the peripheral system and central nervous systems, were used, respectively. Immediately after oral administration of nicorandil (10 mg/kg) or zonisamide (50 mg/kg), the animals were transferred to new home cages. Plasma nicorandil and zonisamide concentrations were determined by high-performance liquid chromatography at 1 and 4 h after administration. Plasma nicorandil concentration in the group transferred to new home cages was significantly decreased relative to levels in the non-transferred control group. However, zonisamide concentrations were unchanged. These findings suggest that the pharmacokinetics of nicorandil, but not those of zonisamide, tend to be influenced by non-physically induced emotional changes.</p>
キーワード psychologically induced emotional changes drug plasma concentration nicorandil zonisamide
Amo Type Article
発行日 2000-02
出版物タイトル Acta Medica Okayama
54巻
1号
出版者 Okayama University Medical School
開始ページ 45
終了ページ 48
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10709622
Web of Sience KeyUT 000085526000007
JaLCDOI 10.18926/AMO/32017
フルテキストURL fulltext.pdf
著者 Yamamoto, Takahiro| Araki, Hiroaki| Futagami, Koujiro| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>It is recognized that sustained ischemia-induced hyperactivity is related to abnormalities in dopamine function. However, it is unclear that dopaminergic neurotransmission triggers such ischemia-induced hyperactivity. Therefore, the relationship between dopaminergic neurotransmission and ischemia-induced hyperactivity was investigated in an animal model using Mongolian gerbils. When haloperidol 2 mg/kg was administered i.p. 30 min after ischemia, the ischemia-induced hyperactivity at 24 h after ischemia was blocked. General behavior was similar to that of sham-operated animals. Haloperidol at doses of 0.1 and 0.2 mg/kg had no effect on locomotor activity in sham-operated animals and decreased ischemia-induced hyperactivity when the drug was administered 24 h after ischemia; these doses did not have any effect on ischemia-induced hyperactivity when the drug was administered 30 min after ischemia. On the other hand, when the animal was confined to a small, restrictive cage for the 24 h period immediately following ischemic injury, locomotor activity at 24 h after ischemia increased. Such behavior also increased in animals when they were returned to their original more permissive cages immediately after ischemia. It is conceivable that the decrease in the level of activity was not related to ischemia-induced hyperactivity. These data suggested that the inhibition of ischemia-induced hyperactivity can be induced by complete blockage of dopaminergic receptors immediately after ischemia.</p>
キーワード ischemia hyperativity dopamine haloperidol Mongolian gerbils
Amo Type Article
発行日 2001-11
出版物タイトル Acta Medica Okayama
55巻
5号
出版者 Okayama University Medical School
開始ページ 277
終了ページ 282
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11688950
Web of Sience KeyUT 000171635400003
JaLCDOI 10.18926/AMO/31837
フルテキストURL fulltext.pdf
著者 Ochi, Rika| Suemaru, Katsuya| Kawasaki, Hiromu| Araki, Hiroaki|
抄録 <p>Theophylline-associated convulsions have been observed most frequently in children with fever, but the mechanism is not fully understood. In this study, we investigated the basic mechanism of aminophylline [theophylline-2-ethylenediamine]-induced convulsions and the effects of Brewer's yeast-induced pyrexia in mice. Diazepam (5-10mg/kg, i.p.), a benzodiazepine receptor agonist, significantly prolonged the onset and significantly decreased the incidence of convulsions induced by aminophylline (350mg/kg, i.p.). However, the gamma aminobutyric acid (GABA)A receptor agonist muscimol (1-4mg/kg, i.p.), the GABAB receptor agonist baclofen (2-4mg/kg, i.p.) and the N-methyl-D-aspartic acid receptor antagonist dizocilpine (0.1-0.3mg/kg, i.p.) failed to protect against the convulsions. 20% Brewer's yeast (0.02ml/g, s.c.) increased body temperature by 1.03, and also significantly shortened the onset and significantly increased the incidence of convulsions induced by aminophylline. The anticonvulsant action of diazepam (2.5-10mg/kg, i.p.) on the convulsions induced by aminophylline was reduced by Brewer's yeast-induced pyrexia. The proconvulsant actions of the GABAA receptor antagonists picrotoxin (3-4mg/kg, i.p.) and pentylenetetrazol (40-60mg/kg, i.p.) were enhanced by Brewer's yeast. These results suggest that the anticonvulsant action of diazepam against aminophylline is reduced by Brewer's yeast-induced pyrexia, and that GABAA receptors are involved in the aggravation of the convulsions by Brewer's yeast in mice.</p>
キーワード theophylline seizures pyrexia Brewer's yeast GABAA receptor
Amo Type Original Article
発行日 2009-10
出版物タイトル Acta Medica Okayama
63巻
5号
出版者 Okayama University Medical School
開始ページ 273
終了ページ 280
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 19893603
Web of Sience KeyUT 000271132000007
JaLCDOI 10.18926/AMO/31835
フルテキストURL fulltext.pdf
著者 Takayama, Fusako| Nakamoto, Kazuo| Kawasaki, Hiromu| Mankura, Mitsumasa| Egashira, Toru| Ueki, Keiji| Hasegawa, Azusa| Okada, Shigeru| Mori, Akitane|
抄録 <p>Vitis coignetiae Pulliat (Yamabudo) is used as a health juice and wine based on the abundant polyphenols and anthocyanins in its fruit. However, it is not known whether the leaves of this plant confer similar benefits. This study investigated the hepatoprotective effects of aqueous extracts from Vitis coignetiae Pulliat leaves (VCPL) in an animal model of nonalcoholic steatohepatitis (NASH). Rats were fed a choline-deficient high-fat diet for four weeks to generate fatty livers. NASH was induced by oxidative stress loading. Ten weeks later, blood and liver samples were collected from anesthetized animals and assessed biochemically, histologically, and histochemically to determine the extent of oxidative stress injury and the overall effects of VCPL. Six-week VCPL extract supplementation reduced serum levels of liver enzymes, decreased CYP2E1 induction, increased plasma antioxidant activities and delayed the progression of liver fibrosis. The findings suggested that VCPL has strong radical-scavenging activity and may be beneficial in preventing NASH progression.</p>
キーワード Yamabudo nonalcoholic steatohepatitis antioxidant hepatoprotection
Amo Type Original Article
発行日 2009-04
出版物タイトル Acta Medica Okayama
63巻
2号
出版者 Okayama University Medical School
開始ページ 105
終了ページ 111
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 19404342
Web of Sience KeyUT 000265457600005
JaLCDOI 10.18926/AMO/31331
フルテキストURL fulltext.pdf
著者 Kawakami, Yasuhiro| Suemaru, Katsuya| Araki, Hiroaki| Kawasaki, Hiromu| Gomita, Yutaka| Tanizaki, Yoshiro|
抄録 <p>The cross-sensitization to stereotyped behavior between mazindol (MZD) and methamphetamine (MAP) was investigated in rats. MZD (5 and 10 mg/kg/day, p.o.), MAP (5 and 10 mg/kg/day, p.o.) and saline (1 ml/kg, p.o.) were administered once daily for a week. Challenge with MZD (10 mg/kg, p.o.) on the 8th day caused markedly stereotyped behavior in MAP-pretreated group compared with the saline-pretreated control group. MAP (10 mg/kg, p.o.)-induced stereotyped behavior on the 8th day was also greater in MZD-pretreated group rather than the saline-pretreated control group. These results suggest that repeated MZD and MAP administration cross-sensitizes to their stereotype-producing effects.</p>
キーワード mazindoi methamphetamine cross-sensitization stereotyped behavior
Amo Type Article
発行日 1998-06
出版物タイトル Acta Medica Okayama
52巻
3号
出版者 Okayama University Medical School
開始ページ 169
終了ページ 171
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9661745
Web of Sience KeyUT 000074528500008
JaLCDOI 10.18926/AMO/31328
フルテキストURL fulltext.pdf
著者 Suemaru, Katsuya| Kawasaki, Hiromu| Yasuhara, Kanako| Yao, Kazuhisa| Furuno, Katusushi| Kawakami, Yasuhiro| Araki, Hiroaki| Gomita, Yutaka| Oka, Eiji|
抄録 <p>Steady-state serum concentrations of carbamazepine (CBZ) and valproic acid (VPA) were investigated in normal weight (body mass index; BMI 20 to 25), lean (smaller than 20 BMI) and moderately obese subjects (greater than 25 BMI) who received either 400 mg/day of CBZ or 800 mg/day of VPA. The CBZ serum concentration in lean subjects was significantly higher than that in normal weight subjects. However, no significant differences in VPA serum concentration were found between the three groups. The CBZ serum concentration decreased with increases in total body weight, and the VPA serum concentration decreased with increases in ideal body weight. However, both serum concentrations were not correlated with BMI. These results suggest that VPA doses should be calculated using ideal body weight and that degree of obesity may affect CBZ serum concentration rather than VPA serum concentration.</p>
キーワード carbamazepine valproic acid serum concentration obesity lean
Amo Type Article
発行日 1998-06
出版物タイトル Acta Medica Okayama
52巻
3号
出版者 Okayama University Medical School
開始ページ 139
終了ページ 142
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9661740
Web of Sience KeyUT 000074528500003
JaLCDOI 10.18926/AMO/30965
フルテキストURL fulltext.pdf
著者 Jin, Xin| Otonashi-Satoh, Yukiko| Sun, Pengyuan| Kawamura, Naomi| Tsuboi, Takashi| Yamaguchi, Yasuyo| Ueda, Taro| Kawasaki, Hiromu|
抄録 <p>The vascular effects of an aqueous extract prepared from the leaves of Eucommia ulmoides Oliv. (ELE), a medicinal herb commonly used in antihypertensive herbal prescriptions in China, were investigated in rat mesenteric resistance arteries. The mesenteric vascular bed was perfused with Krebs solution and the perfusion pressure was measured with a pressure transducer. In preparations with an intact endothelium and precontracted with 7&#956;M methoxamine, perfusion of ELE (10<sup>&#65293;7</sup>&#65293;10<sup>&#65293;2</sup>mg/ml for 15min) caused a concentration-dependent vasodilatation, which was abolished by chemical removal of the endothelium. The ELE-induced vasodilatation was inhibited by neither indomethacin (INDO, a cyclooxygenase inhibitor) nor N<sup>G</sup>-nitro-L-arginine-methyl ester (L-NAME, a nitric oxide inhibitor). The ELE-induced vasodilatation was significantly inhibited by tetraethylammonium (TEA, a K<sup>+</sup> channel blocker) and 18&#945;-glycyrrhetinic acid (18&#945;-GA, a gap-junction inhibitor), and abolished by high K<sup>+</sup> -containing Krebs&#700; solution. Atropine (a muscarinic acetylcholine receptor antagonist) significantly inhibited the vasodilatation induced by ELE at high concentrations. These results suggest that the ELE-induced vasodilatation is endothelium-dependent but nitric oxide (NO)- and prostaglandin I<sub>2</sub> (PGI<sub>2</sub>)-independent, and is mainly mediated by the endothelium-derived hyperpolarizing factor (EDHF) in the mesenteric resistance arteries. Furthermore, the ELE-induced EDHF-mediated response involves the activation of K<sup>+</sup>-channels and gap junctions.</p>
キーワード Eucommia ulmoides Oliv. leaf extract endothelium-dependent vasodilation endothelium-derived hyperpolarizing factor mesenteric resistance artery
Amo Type Original Article
発行日 2008-10
出版物タイトル Acta Medica Okayama
62巻
5号
出版者 Okayama University Medical School
開始ページ 319
終了ページ 325
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18985092
Web of Sience KeyUT 000260391300006
JaLCDOI 10.18926/AMO/30470
フルテキストURL fulltext.pdf
著者 Watanabe, Kazuhide| Matsuka, Naoyuki| Furuno, Katushi| Eto, Kohei| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>In order to evaluate a clinical use of omeprazole suspension, we examined the pharmacokinetics of omeprazole after oral administration in rats. Although the administration of omeprazole suspension buffered by NaHCO3 solution did not produce a significant increase in the area under the concentration-time curve (AUC) value compared with non-buffered group, the administration of NaHCO3 buffer immediately after dosing of omeprazole suspension buffered by NaHCO3 caused a significant increase in the AUC value. These results suggest that the NaHCO3 treatment following the administration of omeprazole buffered suspension effectively decreased the degradation of the compound by gastric acid. Therefore, the successive administration of NaHCO3 solution after the omeprazole dosing seems to be a simple and useful method for the administration to patients who cannot receive tablets.</p>
キーワード omeprazole suspension pharmacokinetics rats
Amo Type Article
発行日 1996-08
出版物タイトル Acta Medica Okayama
50巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 222
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8874584
Web of Sience KeyUT A1996VE60800006
JaLCDOI 10.18926/AMO/30402
フルテキストURL fulltext.pdf
著者 Watanabe, Kazuhide| Eto, Koehi| Furuno, Katsushi| Mori, Takaaki| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>The effect of cigarette smoke on organ weights, lipid peroxidation and plasma biochemical parameters was investigated in male Wistar rats. Daily exposure (for 20 min twice a day) to cigarette smoke for 27 days caused a significant decrease in liver weight and a significant increase in lung weight. The smoke-exposure group showed increased lipid peroxidation in the liver, but not in the lung. In the smoke-exposure group, the GOT, gamma-GTP, total bilirubin and LDH values were significantly higher than those in the control group, while the plasma glucose value was significantly lower. These results suggest that cigarette smoking might induce liver injury by enhancing lipid peroxidation.</p>
キーワード cigarette smoking lipid peroxidation liver function rats
Amo Type Article
発行日 1995-10
出版物タイトル Acta Medica Okayama
49巻
5号
出版者 Okayama University Medical School
開始ページ 271
終了ページ 274
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8585399
Web of Sience KeyUT A1995TC51800008
JaLCDOI 10.18926/AMO/30398
フルテキストURL fulltext.pdf
著者 Moriyama, Masahiro| Domoto, Haruyo| Yamashita, Syoichi| Furuno, Katsushi| Oishi, Ryozo| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.</p>
キーワード phenobarbital pharmacokinetics pregnancy plasma concentrations
Amo Type Article
発行日 1995-10
出版物タイトル Acta Medica Okayama
49巻
5号
出版者 Okayama University Medical School
開始ページ 237
終了ページ 240
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8585393
Web of Sience KeyUT A1995TC51800002