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ID 48668
JaLCDOI
フルテキストURL
著者
Yokoyama, Teruhiko Department of Urology, Kawasaki Medical School
Yamamoto, Yumiko Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
Suzuki, Tomonori Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
Oguma, Keiji Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
Nagai, Atsushi Department of Urology, Kawasaki Medical School
抄録
Several studies have demonstrated the efficacy of intraprostatic injection of botulinum neurotoxin type A (BoNT/A) against symptomatic benign prostatic hyperplasia (BPH). The most commonly used BoNT/A product, Botox®, forms large complexes and composed of neurotoxin (NTX) as well as non-toxic components. We purified NTX lacking non-toxic components. We investigated the efficacy of this newly purified NTX for men with BPH. Ten male patients (mean age, 70.0 years) with BPH received 100 units (prostate volume [PV] <30ml) or 200 units (PV ァ30ml) of NTX injected into the prostate via a minimally invasive outpatient technique. Evaluation included uroflowmetry, postvoid residual urine volume (PVR), PV, and International Prostate Symptom Score (IPSS) measured at baseline and 1, 3, 6, and 12 months post-treatment. The status of 7 of the 10 patients examined was found to have improved within 1 month of treatment. The mean IPSS decreased from 23.8±7.0 to 16.3±10.3 (p=0.0093) at 1 month, to 14.9±8.2 (p=0.0074) at 3 months, and to 16.9±7.3 (p=0.018) at 12 months. The mean PV decreased from 47.8±21.2 to 39.2±19.5ml (p=0.0076) at 3 months. The PVR improved at 3 and 6 months post-treatment. Intraprostatic NTX injection induces prostate shrinkage and is effective in men with BPH.
キーワード
botulinum neurotoxin type A
benign prostatic hyperplasia
therapy
Amo Type
Original Article
発行日
2012-08
出版物タイトル
Acta Medica Okayama
66巻
4号
出版者
Okayama University Medical School
開始ページ
291
終了ページ
297
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT