ID | 53008 |
フルテキストURL | |
著者 |
Murakami, Shinki
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Brain Sci
Miyazaki, Ikuko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Brain Sci
ORCID
Kaken ID
publons
researchmap
Sogawa, Norio
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Dent Pharmacol
Miyoshi, Ko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Brain Sci
Asanuma, Masato
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Brain Sci
Kaken ID
publons
researchmap
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抄録 | Parkinson's disease (PD) is a neurodegenerative disease with motor symptoms as well as non-motor symptoms that precede the onset of motor symptoms. Mitochondrial complex I inhibitor, rotenone, has been widely used to reproduce PD pathology in the central nervous system (CNS) and enteric nervous system (ENS). We reported previously that metallothioneins (MTs) released from astrocytes can protect dopaminergic neurons against oxidative stress. The present study examined the changes in MT expression by chronic systemic rotenone administration in the striatum and colonic myenteric plexus of C57BL mice. In addition, we investigated the effects of MT depletion on rotenone-induced neurodegeneration in CNS and ENS using MT-1 and MT-2 knockout (MT KO) mice, or using primary cultured neurons from MT KO mice. In normal C57BL mice, subcutaneous administration of rotenone for 6 weeks caused neurodegeneration, increased MT expression with astrocytes activation in the striatum and myenteric plexus. MT KO mice showed more severe myenteric neuronal damage by rotenone administration after 4 weeks than wild-type mice, accompanied by reduced astroglial activation. In primary cultured mesencephalic neurons from MT KO mice, rotenone exposure induced neurotoxicity in dopaminergic neurons, which was complemented by addition of recombinant protein. The present results suggest that MT seems to provide protection against neurodegeneration in ENS of rotenone-induced PD model mice.
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キーワード | Parkinson's disease
Rotenone
Enteric nervous system
Astrocytes
Metallothionein
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発行日 | 2014-10
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出版物タイトル |
Neurotoxicity Research
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巻 | 26巻
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号 | 3号
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出版者 | Springer
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開始ページ | 285
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終了ページ | 298
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ISSN | 1029-8428
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資料タイプ |
学術雑誌論文
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52964
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言語 |
英語
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |