ID | 47025 |
JaLCDOI | |
Sort Key | 6
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フルテキストURL | |
著者 |
Hikida, Masaki
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University
Magari, Masaki
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University
Kaken ID
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Nakayama, Yasunori
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University
Kanayama, Naoki
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University
Ohmori, Hitoshi
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University
Kaken ID
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抄録 | A population of peripheral B cells have been shown to express recombination activating gene products, RAG-1 and RAG-2, which are considered to be involved in revising the B cell antigen receptor (BCR) in the periphery. BCR engagement has been reported to turn off RAG expression in peripheral B cells, whereas the same treatment has an opposite effect in immature B cells in the bone marrow. In contrast to receptor editing that is involved in the removal of autoreactivity in immature B cells, it has been shown that secondary V(D)J rearrangement in peripheral B cells, termed receptor revision, contributes to affinity maturation of antibodies. Here, we show that RAG-2 expression in murine splenic B cells was abrogated by the coligation of BCR with complement receptors (CD21/CD35) much more efficiently than by the engagement of BCR alone. On the other hand, the same coligation augmented proliferation of anti-CD40-stimulated B cells. Consistent with these observations, RAG-2 expression was lower in the draining lymph nodes of the quasi-monoclonal mice when they were immunized with a high-affinity antigen than with a low-affinity one. These findings suggest a crucial role for CD21/CD35 in directing the conservation or the revision of
BCRs in peripheral B cells.
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出版物タイトル |
Memoirs of the Faculty of Engineering, Okayama University
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発行日 | 2002-03
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巻 | 36巻
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号 | 2号
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出版者 | Faculty of Engineering, Okayama University
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開始ページ | 51
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終了ページ | 60
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ISSN | 0475-0071
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NCID | AA10699856
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資料タイプ |
紀要論文
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OAI-PMH Set |
岡山大学
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言語 |
英語
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論文のバージョン | publisher
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NAID | |
Eprints Journal Name | mfe
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