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ID 58670
著者
Ueda, Yayoi Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tokumasu, Kazuki Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID publons researchmap
Hagiya, Hideharu Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Iio, Koji Microbiology Division, Clinical Laboratory, Okayama University Hospital
Fujimori, Takumi Microbiology Division, Clinical Laboratory, Okayama University Hospital
Kakehi, Ayaka Microbiology Division, Clinical Laboratory, Okayama University Hospital
Okura, Mami Microbiology Division, Clinical Laboratory, Okayama University Hospital
Minabe, Hiroshi Microbiology Division, Clinical Laboratory, Okayama University Hospital
Otsuka, Fumio Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
抄録
Mycobacterium chelonae is a rapidly growing mycobacterium that has the potential to cause refractory infections in humans. Mycobacteremia resulting from the organism is extremely rare, and its clinical features are yet to be uncovered. We herein present a case of M. chelonae bloodstream infection involving an immunocompromised older patient. A 79-year-old woman, on a long-term treatment with prednisolone plus tacrolimus for rheumatoid arthritis, visited our outpatient department complaining of deteriorating pain and swelling at her right 1st toe. Laboratory parameters showed elevated C-reactive protein and leukocytosis, and magnetic resonance imaging indicated osteomyelitis at the proximal phalanx of her right 1st toe. Considering the refractory course, the infected toe was immediately amputated. M. chelonae was isolated from bacterial cultures of the resected tissue and blood (BD BACTEC™ FX blood culture system, Becton Dickinson, Sparks, MD, USA), leading to a diagnosis of disseminated M. chelonae infection. We treated the patient with an antibiotic combination of clarithromycin, minocycline, and imipenem (2 weeks), which was converted to oral therapy of clarithromycin, doxycycline, and levofloxacin. This case highlighted the potential pathogenesis of M. chelonae to cause mycobacteremia in an immunocompromised patient.
キーワード
Mycobacterium chelonae
Mycobacteremia
Non-tuberculous mycobacteria
Osteomyelitis
Rapidly growing mycobacteria
Rheumatoid arthritis
備考
This fulltext is available in May 2021.
発行日
2020-05-11
出版物タイトル
Journal of Infection and Chemotherapy
26巻
8号
出版者
Elsevier
開始ページ
843
終了ページ
846
ISSN
1341321X
NCID
AA11057978
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
論文のバージョン
author
PubMed ID
DOI
関連URL
isVersionOf https://doi.org/10.1016/j.jiac.2020.03.004