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ID 60235
フルテキストURL
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著者
Masaoka, Yasuyuki Department of Pharmacy, Okayama University Hospital
Kawasaki, Yoichi Department of Pharmacy, Okayama University Hospital Kaken ID publons researchmap
Kikuoka, Ryo Department of Clinical Pharmacy,Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Ogawa, Atsushi Department of Pharmacy, Okayama University Hospital
Esumi, Satoru Department of Pharmacy, Okayama University Hospital
Wada, Yudai Department of Clinical Pharmacy,Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Ushio, Soichiro Department of Pharmacy, Okayama University Hospital
Kitamura, Yoshihisa Department of Pharmacy, Okayama University Hospital ORCID Kaken ID publons researchmap
Sendo, Toshiaki Department of Pharmacy, Okayama University Hospital Kaken ID researchmap
抄録
Background
Valganciclovir (VGC) is essential for preventing cytomegalovirus infections after transplants in adult and pediatric patients. In pediatric patients, VGC tablets have to be pulverized so that they can be delivered via nasogastric tubes. The “simple suspension method” is usually used to suspend tablets in hot water in Japan. However, the optimal suspension conditions and metering methods for preparing VGC suspensions using the simple suspension method are unclear. The purpose of this study was to clarify these issues.
Methods
VGC tablets were suspended in water (initial water temperature: 25 °C or 55 °C) using the simple suspension method. The residual rate of VGC after it had been suspended in hot water was determined using HPLC. In addition, the suspended solution was passed through 6, 8, and 12 Fr. gavage tubes. The VGC concentrations of suspensions produced using different preparation methods were also determined using HPLC.
Results
Cracking the surfaces of VGC tablets and suspending them in water at an initial temperature of 55 °C was effective at dissolving the tablets. The VGC concentration of the suspension remained stable for at least 80 min. Furthermore, the VGC concentration remained stable for 48 h during cold dark storage. Cracking the surfaces of VGC tablets could be a more effective metering method than preparing powder from VGC tablets. In addition, little VGC remained in 6, 8, or 12 Fr. gavage tubes after VGC solution was passed through them.
Conclusion
The amount of VGC should be measured carefully when preparing VGC solutions using the simple suspension method.
キーワード
Valganciclovir
Simple suspension method
Stability
HPLC
Gavage tube
発行日
2020-07-07
出版物タイトル
Journal of Pharmaceutical Health Care and Sciences
6巻
1号
出版者
BMC
開始ページ
16
ISSN
2055-0294
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© The Author(s). 2020
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1186/s40780-020-00172-w
ライセンス
http://creativecommons.org/licenses/by/4.0/