ID | 47013 |
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フルテキストURL | |
著者 |
Wang, Lei
Department of Urology, Peking University People's Hospital
Kaku, Haruki
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Huang, Peng
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Xu, Kexin
Department of Urology, Peking University People's Hospital
Yang, Kai
Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University
Zhang, Jiheng
Department of Urology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
Li, Ming
Department of Urology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
Xie, Liping
Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University
Wang, Xiaofeng
Department of Urology, Peking University People's Hospital
Sakai, Akiko
Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
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Watanabe, Masami
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Nasu, Yasutomo
Research and Develop Center for Advanced Clinical Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Shimizu, Kenji
Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Kumon, Hiromi
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Na, Yanqun
Department of Urology, Peking University People's Hospital
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抄録 | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR=0.58, 95%CI:0.35-0.97, p=0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR=0.27, 95%CI:0.12-0.61, p=0.002) and in patients with localized diseases (OR=0.36, 95%CI:0.19-0.70, p=0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.
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キーワード | polymorphism
prostatic neoplasms
single nucleotide
susceptibility
WRN
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Amo Type | Original Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2011-10
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巻 | 65巻
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号 | 5号
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出版者 | Okayama University Medical School
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開始ページ | 315
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終了ページ | 323
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2011 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |