JaLCDOI 10.18926/AMO/54600
フルテキストURL 70_5_397.pdf
著者 Akagi, Satoshi| Nakamura, Kazufumi| Akagi, Teiji| Nakagawa, Koji| Takaya, Yoichi| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi|
抄録 A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD.
キーワード pulmonary hypertension atrial septal defect repair and treat transcatheter closure
Amo Type Clinical Study Protocols
発行日 2016-10
出版物タイトル Acta Medica Okayama
70巻
5号
出版者 Okayama University Medical School
開始ページ 397
終了ページ 400
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27777434
Web of Sience KeyUT 000388098700011
JaLCDOI 10.18926/AMO/53519
フルテキストURL 69_3_129.pdf
著者 Akagi, Satoshi| Nakamura, Kazufumi| Matsubara, Hiromi| Ogawa, Aiko| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi|
抄録 Pulmonary arterial hypertension (PAH) is characterized by elevation of pulmonary artery pressure caused by pulmonary vasoconstriction and vascular remodeling, which leads to right heart failure and death. Epoprostenol (prostaglandin I2) has a potent short-acting vasodilator property, and intravenous continuous epoprostenol is therefore used for treatment of PAH. Here we review evidence for the usefulness of intravenous continuous epoprostenol therapy in patients with PAH. Epoprostenol therapy is effective in idiopathic PAH patients and in patients with PAH associated with connective tissue disease, portal hypertension or congenital heart diseases, but it is not effective in patients with pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. High-dose epoprostenol therapy markedly improved hemodynamics in some patients with PAH, possibly due to reverse remodeling of pulmonary arteries. This therapy has several side effects and complications such as headache, hypotension and catheter-related infections. Intravenous continuous epoprostenol is an effective treatment, but there are still some problems to be resolved.
キーワード pulmonary arterial hypertension epoprostenol high-dose complications side effects
Amo Type Review
発行日 2015-06
出版物タイトル Acta Medica Okayama
69巻
3号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 136
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26101188
Web of Sience KeyUT 000356903000001
著者 Kobayashi, Junko| Yoshida, Masashi| Tarui, Suguru| Hirata, Masataka| Nagai, Yusuke| Kasahara, Shingo| Naruse, Keiji| Ito, Hiroshi| Sano, Shunji| Oh, Hidemasa|
発行日 2014-07-22
出版物タイトル PLoS ONE
9巻
7号
資料タイプ 学術雑誌論文
著者 Tokioka, Koji| Kusano, Kengo F.| Morita, Hiroshi| Miura, Daiji| Nishii, Nobuhiro| Nagase, Satoshi| Nakamura, Kazufumi| Kohno, Kunihisa| Ito, Hiroshi| Ohe, Tohru|
発行日 2014-05-27
出版物タイトル Journal of the American College of Cardiology
63巻
20号
資料タイプ 学術雑誌論文
著者 Dan, Kazuhiro| Miyoshi, Toru| Ueeda, Masayuki| Ohtsuka, Hiroaki| Ugawa, Satoko| Ohnishi, Nobuhiko| Takaishi, Atsushi| Nakamura, Kazufumi| Kusano, Kengo| Ito, Hiroshi|
発行日 2012-09
出版物タイトル Circulation Journal
76巻
9号
資料タイプ 学術雑誌論文
著者 Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi|
発行日 2013-02-19
出版物タイトル PLoS ONE
8巻
2号
資料タイプ 学術雑誌論文
著者 Wada, Tadashi| Nakahama, Makoto| Toda, Hironobu| Watanabe, Atsuyuki| Hashimoto, Katsushi| Terasaka, Ritsuko| Nakamura, Kazufumi| Yamada, Nobuyuki| Ito, Hiroshi|
発行日 2013
出版物タイトル ISRN Cardiology
2013巻
資料タイプ 学術雑誌論文
著者 Nosaka, Kazumasa| Nakamura, Kazufumi| Kusano, Kengo| Toh, Norihisa| Tada, Takeshi| Miyoshi, Toru| Doi, Masayuki| Kohno, Kunihisa| Morita, Hiroshi| Ito, Hiroshi|
発行日 2013-08
出版物タイトル Congestive Heart Failure
19巻
4号
資料タイプ 学術雑誌論文
著者 溝口 博喜| 小川 愛子| 宗政 充| 三河内 弘| 伊藤 浩| 松原 広己|
発行日 2013-12-02
出版物タイトル 岡山医学会雑誌
125巻
3号
資料タイプ 学術雑誌論文
著者 中村 一文| 伊藤 浩|
発行日 2012-04-01
出版物タイトル 岡山医学会雑誌
124巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/31817
フルテキストURL fulltext.pdf
著者 Ito, Hiroshi|
抄録 <p>For patients with acute myocardial infarction (MI), the immediate therapeutic goal is to establish the patency of the infarct-related artery. Prolonged myocardial ischemia, however, often breaks down the coronary microvasculature, and the flow to the infarct myocardium may be markedly reduced. This is called the no-reflow phenomenon. This phenomenon is important not solely because it correlates with infarct size but because it provides additional prognostic information. With recent advances in imaging modalities, the no-reflow phenomenon is observed more frequently than when clinical judgment alone is used. Patients with this phenomenon are associated with poor functional and clinical outcomes. Now, the no-reflow phenomenon can be a parameter with which to predict high-risk patients. The focus of reperfusion therapy has shifted toward the improvement of myocardial perfusion. The improvement of myocardial perfusion could promote the functional recovery of viable muscle and reduce infarct expansion, which is associated with favorable clinical outcomes. For this purpose, pharmacological interventions and catheter-based devices to retrieve embolic materials have been proposed. Advances in our understanding of the pathophysiology of microvascular dysfunction would aid the development of therapeutic strategies for its prevention and treatment.</p>
キーワード cardiac function coronary intervention microcirculation myocardial infarction reperfusion
Amo Type Review
発行日 2009-08
出版物タイトル Acta Medica Okayama
63巻
4号
出版者 Okayama University Medical School
開始ページ 161
終了ページ 168
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 19727200
Web of Sience KeyUT 000269228400001
著者 伊藤 浩|
発行日 2009-08-03
出版物タイトル 岡山医学会雑誌
121巻
2号
資料タイプ 学術雑誌論文