ID | 46944 |
フルテキストURL | |
著者 |
Ishimoto, Hidekazu
Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shibata, Mari
Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Myojin, Yuki
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University
Ito, Hideyuki
Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
Sugimoto, Yukio
Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Tai, Akihiro
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
Hatano, Tsutomu
Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
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researchmap
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抄録 | Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.
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キーワード | Ellagitannin
Urolithin A
Antioxidant activity
Anti-inflammatory activity
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発行日 | 2011-10-01
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出版物タイトル |
Bioorganic & Medicinal Chemistry Letters
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巻 | 21巻
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号 | 19号
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出版者 | Pergamon-Elsevier Science Ltd.
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開始ページ | 5901
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終了ページ | 5904
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ISSN | 0960-894X
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NCID | AA1079577X
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | © 2011 Elsevier Ltd. All rights reserved.
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論文のバージョン | author
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査読 |
有り
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DOI | |
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