ID | 31982 |
JaLCDOI | |
フルテキストURL | |
著者 |
Yumoto, Akihisa
Okayama University
Kusano, Kengo Fukushima
Okayama University
Hashimoto, Katsushi
Okayama University
Aoki, Motokuni
Geriatric Medicine
Morishita, Ryuichi
Okayama University
Kaneda, Yasufumi
Okayama University
Ohe, Tohru
Okayama University
|
抄録 | It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia. To investigate this possibility, we examined the antiarrhythmic effect of HGF gene therapy in rat acute and old myocardial infarction models. Myocardial ischemia was induced by ligation of the left descending coronary artery. Hemagglutinating virus of Japan (HVJ)-coated liposome containing HGF genes were injected directly into the myocardium fourteen days before programmed pacing. Ventricular fibrillation (VF)was induced by programmed pacing. The VF duration was reduced and the VF threshold increased after HGF gene therapy ( p< 0.01). Histological analyses revealed that the number of vessels in the ischemic border zone was greatly increased after HGF gene injection. These findings revealed that HGF gene therapy has an anti-arrhythmic effect after myocardial ischemia. |
キーワード | ventricular arrhythmia
HGF (hepatocyte growth factor)
ischemia
HVJ (hemagglutinating virus of Japan)
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2005-06
|
巻 | 59巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 73
|
終了ページ | 78
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |