ID | 63772 |
フルテキストURL | |
著者 |
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
Ishida, Tsuyoshi
Graduate School of Health Sciences, Okayama University
Naoe, Shota
Graduate School of Health Sciences, Okayama University
Kanzaki, Norie
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Sakoda, Akihiro
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Tanaka, Hiroshi
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Mitsunobu, Fumihiro
Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
Kaken ID
publons
researchmap
Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
Kaken ID
publons
researchmap
|
抄録 | Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m(3) and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m(3)) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m(3)) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m(3) thoron inhalation was lower than that after 500 Bq/m(3) thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m(3) and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m(3) was more effective than that at 2000 Bq/m(3), possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m(3) and AA administration promoted an early recovery from alcohol-induced liver damage.
|
キーワード | alcohol-induced liver damage
oxidative stress
antioxidative function
ascorbic acid (AA)
thoron
|
発行日 | 2022-07-11
|
出版物タイトル |
Journal Of Radiation Research
|
出版者 | Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.
|
ISSN | 0449-3060
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © The Author(s) 2022.
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1093/jrr/rrac046
|
ライセンス | https://creativecommons.org/licenses/by-nc/4.0/
|