ID | 62046 |
フルテキストURL | |
著者 |
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
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Kanzaki, Norie
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Sakoda, Akihiro
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Shuto, Hina
Graduate School of Health Sciences, Okayama University
Yano, Junki
Graduate School of Health Sciences, Okayama University
Naoe, Shota
Graduate School of Health Sciences, Okayama University
Tanaka, Hiroshi
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Hanamoto, Katsumi
Graduate School of Health Sciences, Okayama University
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Terato, Hiroaki
Advanced Science Research Center, Okayama University
Mitsunobu, Fumihiro
Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University
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Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
Kaken ID
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抄録 | Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m(3) for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs.
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キーワード | radon
redox state
oxidative stress
antioxidative function
principal component analysis
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発行日 | 2021-01-27
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出版物タイトル |
Journal of Radiation Research
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巻 | 62巻
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号 | 3号
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出版者 | Oxford Univ Press
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開始ページ | 390
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終了ページ | 400
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ISSN | 0449-3060
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2021.
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論文のバージョン | publisher
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DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1093/jrr/rraa129
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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助成機関名 |
JAEA Nuclear Energy S&T and Human Resource Development Project through Concentrating Wisdom
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助成番号 | JPJA18B18072098
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オープンアクセス(出版社) |
OA
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