ID | 58756 |
著者 |
Isoshima, Daichi
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Matsunaga, Kazuyuki
Okayama University Hospital
Taniguchi, Makoto
Oral Microbiome Center, Taniguchi Dental Clinic
Matsubara, Takehiro
Okayama University Hospital
Ota, Shinzo
Department of Neurology, Brain Attack Center Ota Memorial Hospital
Sato, Michiyoshi
Department of Neurology, Brain Attack Center Ota Memorial Hospital
Shimoe, Yutaka
Department of Neurology, Brain Attack Center Ota Memorial Hospital
Kohriyama, Tatsuo
Department of Neurology, Brain Attack Center Ota Memorial Hospital
Arias, Zulema
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Yamamoto, Tadashi
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Takashiba, Shogo
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
Kaken ID
publons
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抄録 | There is no conclusive evidence regarding a causal relationship between periodontitis and atherosclerosis. In this study, we examined the microbiome in the oral cavity and atheromatous plaques from atherosclerosis patients with or without periodontitis to investigate the role of oral bacteria in the formation of atheromatous plaques. We chose four patients with and without periodontitis, who had undergone carotid endarterectomy. Bacterial samples were extracted from the tongue surface, from periodontal pocket (during the oral examination), and from the atheromatous plaques (APs). We investigated the general and oral conditions from each patient and performed next-generation sequencing (NGS) analysis for all bacterial samples. There were no significant differences between both groups concerning general conditions. However, the microbiome patterns of the gingival pocket showed differences depending on the absence or presence of periodontitis, while those of the tongue surface were relatively similar. The microbiome pattern of the atheromatous plaques was entirely different from that on the tongue surface and gingival pocket, and oral bacteria were seldom detected. However, the microbiome pattern in atheromatous plaques was different in the presence or absence of periodontitis. These results suggested that oral bacteria did not affect the formation of atheromatous plaques directly.
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キーワード | Microbiome
Atherosclerosis
Periodontitis
Next-generating sequencing
Oral bacteria
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備考 | metadata only access
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発行日 | 2020-05-19
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出版物タイトル |
Odontology
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巻 | 109巻
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出版者 | Springer
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開始ページ | 239
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終了ページ | 249
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ISSN | 16181247
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NCID | AA11580928
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | none
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1007/s10266-020-00524-w
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