ID | 32110 |
JaLCDOI | |
フルテキストURL | |
著者 |
Shinji, Toshiyuki
Okayama University
Kyaw, Yi Yi
Lower Myanmar
Gokan, Katsunori
Okayama University
Tanaka, Yasuhito
Nagoya City University
Ochi, Koji
Okayama University
Fujioka, Shin-ichi
Okayama University
Lwin, Aye Aye
Okayama University
Shiratori, Yasushi
Okayama University
Mizokami, Masashi
Nagoya City University
Khin, Myo
Medical Research(Lower Myanmar)
Miyahara, Masayuki
Okayama Red Cross Blood Center
Okada, Shigeru
Okayama University
Koide, Norio
Okayama University
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抄録 | The prevalence of hepatitis C virus (HCV) genotypes in Myanmar in comparison with the rest of Southeast Asia is not well known. Serum samples were obtained from 201 HCV antibody-positive volunteer blood donors in and around the Myanmar city of Yangon. Of these, the antibody titers of 101 samples were checked by serial dilution using HCV antibody PA test II and Terasaki microplate as a low-cost method. To compare antibody titers by this method and RNA identification, we also checked HCV-RNA using the Amplicor 2.0 test. Most high-titer groups were positive for HCV-RNA. Of the 201 samples, 110 were successfully polymerase chain reaction (PCR) amplified. Among them, 35 (31.8%) were of genotype 1, 52 (47.3%) were of genotype 3, and 23 (20.9%) were of type 6 variants, and phylogenetic analysis of these type 6 variants revealed that 3 new type 6 subgroups exist in Myanmar. We named the subgroups M6-1, M6-2, and M6-3. M6-1 and M6-2 were relatively close to types 8 and 9, respectively. M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed.
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キーワード | hepatitis C virus(HCV)genotype
type 6 variant
Myanmar
Southeast Asia
phylogenetic analysis
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Amo Type | Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2004-06
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巻 | 58巻
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号 | 3号
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出版者 | Okayama University Medical School
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開始ページ | 135
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終了ページ | 142
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |