| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yoshida, Akari| Ohtsuka, Satomi| Matsumoto, Fumiya| Miyagawa, Tomoyuki| Okino, Rei| Ikeda, Yumeya| Tada, Natsume| Gotoh, Akira| Magari, Masaki| Hatano, Naoya| Morishita, Ryo| Satoh, Ayano| Sunatsuki, Yukinari| Nilsson, Ulf J.| Ishikawa, Teruhiko| Tokumitsu, Hiroshi| |
| 備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-57051-9| |
| 発行日 | 2024-03-20 |
| 出版物タイトル | Scientific Reports |
| 巻 | 14巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 6723 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38509168 |
| DOI | 10.1038/s41598-024-57051-9 |
| Web of Science KeyUT | 001192455600061 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-024-57051-9 |
| フルテキストURL | fulltext20220602-1.pdf |
|---|---|
| 著者 | Kaneshige, Riku| Ohtsuka, Satomi| Harada, Yuhei| Kawamata, Issei| Magari, Masaki| Kanayama, Naoki| Hatano, Naoya| Sakagami, Hiroyuki| Tokumitsu, Hiroshi| |
| キーワード | AMP-activated protein kinase Arg/Pro-rich insert domain (RP-domain) calcium/calmodulin-dependent protein kinase calcium/calmodulin-dependent protein kinase kinase substrate recognition |
| 備考 | This is the peer reviewed version of the following article: [Kaneshige, R., Ohtsuka, S., Harada, Y., Kawamata, I., Magari, M., Kanayama, N., Hatano, N., Sakagami, H. and Tokumitsu, H. (2022), Substrate recognition by Arg/Pro-rich insert domain in calcium/calmodulin-dependent protein kinase kinase for target protein kinases. FEBS J, 289: 5971-5984. https://doi.org/10.1111/febs.16467], which has been published in final form at [https://doi.org/10.1111/febs.16467]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext will be available in May 2023.| |
| 発行日 | 2022-05-17 |
| 出版物タイトル | The FEBS Journal |
| 巻 | 289巻 |
| 号 | 19号 |
| 出版者 | Wiley |
| 開始ページ | 5971 |
| 終了ページ | 5984 |
| ISSN | 1742-464X |
| NCID | AA11998513 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Federation of European Biochemical Societies. |
| 論文のバージョン | author |
| PubMed ID | 35490408 |
| DOI | 10.1111/febs.16467 |
| Web of Science KeyUT | 000796673600001 |
| 関連URL | isVersionOf https://doi.org/10.1111/febs.16467 |
| フルテキストURL | fulltext20220509-1.pdf Supporting_Information20220509-1.pdf |
|---|---|
| 著者 | Ohtsuka, Satomi| Okumura, Taisei| Τabuchi, Yuna| Miyagawa, Tomoyuki| Kanayama, Naoki| Magari, Masaki| Hatano, Naoya| Sakagami, Hiroyuki| Suizu, Futoshi| Ishikawa, Teruhiko| Tokumitsu, Hiroshi| |
| 備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biochemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biochem.1c00796| |
| 発行日 | 2022-03-11 |
| 出版物タイトル | Biochemistry |
| 巻 | 61巻 |
| 号 | 7号 |
| 出版者 | American Chemical Society (ACS) |
| 開始ページ | 545 |
| 終了ページ | 553 |
| ISSN | 0006-2960 |
| NCID | AA00564599 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Copyright © 2022 American Chemical Society |
| 論文のバージョン | author |
| DOI | 10.1021/acs.biochem.1c00796 |
| Web of Science KeyUT | 000783678600007 |
| 関連URL | isVersionOf https://doi.org/10.1021/acs.biochem.1c00796 |
| フルテキストURL | fulltext20220106-5.pdf |
|---|---|
| 著者 | Fukumoto, Yusei| Harada, Yuhei| Ohtsuka, Satomi| Kanayama, Naoki| Magari, Masaki| Hatano, Naoya| Sakagami, Hiroyuki| Tokumitsu, Hiroshi| |
| キーワード | CaMKK oligomerization Ca2+-signaling phosphorylation CaM kinase cascade |
| 備考 | © 2021 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbrc.2021.11.105] .| |
| 発行日 | 2022-1 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 587巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 160 |
| 終了ページ | 165 |
| ISSN | 0006-291X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Elsevier Inc. |
| 論文のバージョン | author |
| PubMed ID | 34875535 |
| DOI | 10.1016/j.bbrc.2021.11.105 |
| Web of Science KeyUT | 000729413200005 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.bbrc.2021.11.105 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamamoto, Maho| Kondo, Rina| Hozumi, Haruka| Doi, Seita| Denda, Miwako| Magari, Masaki| Kanayama, Naoki| Hatano, Naoya| Morishita, Ryo| Tokumitsu, Hiroshi| |
| キーワード | S100 protein HMG20A protein-protein interaction Ca2+-signal transduction genome-wide screening |
| 発行日 | 2021-03-30 |
| 出版物タイトル | Biomolecules |
| 巻 | 11巻 |
| 号 | 4号 |
| 出版者 | MDPI |
| 開始ページ | 510 |
| ISSN | 2218-273X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 33808200 |
| NAID | 120007037385 |
| DOI | 10.3390/biom11040510 |
| Web of Science KeyUT | 000642769800001 |
| 関連URL | isVersionOf https://doi.org/10.3390/biom11040510 |
| JaLCDOI | 10.18926/47025 |
|---|---|
| フルテキストURL | mfe_36_2_051_060.pdf |
| 著者 | Hikida, Masaki| Magari, Masaki| Nakayama, Yasunori| Kanayama, Naoki| Ohmori, Hitoshi| |
| 抄録 | A population of peripheral B cells have been shown to express recombination activating gene products, RAG-1 and RAG-2, which are considered to be involved in revising the B cell antigen receptor (BCR) in the periphery. BCR engagement has been reported to turn off RAG expression in peripheral B cells, whereas the same treatment has an opposite effect in immature B cells in the bone marrow. In contrast to receptor editing that is involved in the removal of autoreactivity in immature B cells, it has been shown that secondary V(D)J rearrangement in peripheral B cells, termed receptor revision, contributes to affinity maturation of antibodies. Here, we show that RAG-2 expression in murine splenic B cells was abrogated by the coligation of BCR with complement receptors (CD21/CD35) much more efficiently than by the engagement of BCR alone. On the other hand, the same coligation augmented proliferation of anti-CD40-stimulated B cells. Consistent with these observations, RAG-2 expression was lower in the draining lymph nodes of the quasi-monoclonal mice when they were immunized with a high-affinity antigen than with a low-affinity one. These findings suggest a crucial role for CD21/CD35 in directing the conservation or the revision of BCRs in peripheral B cells. |
| 出版物タイトル | Memoirs of the Faculty of Engineering, Okayama University |
| 発行日 | 2002-03 |
| 巻 | 36巻 |
| 号 | 2号 |
| 開始ページ | 51 |
| 終了ページ | 60 |
| ISSN | 0475-0071 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 80015582223 |
| JaLCDOI | 10.18926/46955 |
|---|---|
| フルテキストURL | mfe_38_1-2_091_096.pdf |
| 著者 | Kanayama, Naoki| Yamakoshi, Kimi| Kiyomi, Masaaki| Magari, Masaki| Ohmori, Hitoshi| |
| 抄録 | Generally, IgM antibodies (Abs) produced in a primary immune response show lower affinity for an inducing antigen (Ag) compared with the corresponding IgG Abs that are major switched isotypes formed in the secondary response. An IgM molecule is a pentamer with 10 Ag-binding sites that will contribute to an increase of avidity for an Ag. To estimate the contribution of the pentameric structure to the avidity of an IgM Ab, we generated IgM and IgG1 monoclonal Abs (mAbs) with identical V regions that are specific for 4-hydroxy-3-nitrophenylacetyl (NP) by in vitro class switching of B cells followed by the cell fusion with a mouse myeloma cell line. Compared with an anti-NP IgG1 mAb, the corresponding IgM mAb showed much higher avidity for NP-conjugated bovine serum albumin, which was drastically reduced after being dissociated into monomers. |
| 出版物タイトル | Memoirs of the Faculty of Engineering, Okayama University |
| 発行日 | 2004-03 |
| 巻 | 38巻 |
| 号 | 1-2号 |
| 開始ページ | 91 |
| 終了ページ | 96 |
| ISSN | 0475-0071 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 80017001822 |
| 著者 | 曲 正樹| |
|---|---|
| 発行日 | 2002-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |