ID | 52345 |
フルテキストURL | |
著者 |
Kagawa, Hidetoshi
Himeji Red Cross Hosp, Dept Internal Med
Hiromasa, Tsutomu
Himeji Red Cross Hosp, Dept Internal Med
Hara, Takayuki
Himeji Red Cross Hosp, Dept Internal Med
Takaki, Ayako
Himeji Red Cross Hosp, Dept Internal Med
Yamanaka, Ryutaro
Himeji Red Cross Hosp, Dept Internal Med
Sada, Ken-ei
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
ORCID
Kaken ID
researchmap
Makino, Hirofumi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
ORCID
Kaken ID
publons
researchmap
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抄録 | Conventional cyclophosphamide-based treatment regimens for lupus nephritis (LN) are still not considered to be optimal. The aim of this study was to evaluate the efficacy and safety of mizoribine, tacrolimus, and corticosteroid combination therapy for LN.
We retrospectively evaluated a combination treatment of mizoribine and tacrolimus with corticosteroids as induction therapy in eight newly diagnosed systemic lupus erythematosus (SLE) patients with biopsy-proven LN.
All patients were women, and their mean [standard deviation (SD)] age was 48.5 (20) years. All patients (100 %) had positive anti-double-stranded DNA (anti-dsDNA) antibody titers, and four (50.0 %) were nephrotic. Mean (SD) serum creatinine and daily proteinuria levels were 0.72 (0.4) mg/dl (range 0.33-1.55 mg/dl) and 4.56 (2.8) g (range 0.77-8.2 g), respectively. By month 2, significant improvements in the anti-dsDNA antibody titers, levels of proteinuria, serum albumin, and C3, and SLE disease activity index score were observed. By month 6, seven patients (87.5 %) were in complete remission, with normalized levels of both proteinuria and serum creatinine.
This pilot study suggests that mizoribine and tacrolimus treatment with corticosteroids is well tolerated and may prove to be an optimal alternative remission-inducing regimen for LN.
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キーワード | Induction therapy
Lupus nephritis
Mizoribine
Multitarget therapy
Systemic lupus erythematosus
Tacrolimus
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備考 | The original publication is available at www.springerlink.com
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発行日 | 2012-10
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出版物タイトル |
Clinical and Experimental Nephrology
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巻 | 16巻
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号 | 5号
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出版者 | Springer
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開始ページ | 760
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終了ページ | 766
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ISSN | 1342-1751
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資料タイプ |
学術雑誌論文
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52252
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言語 |
英語
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |