ID | 67237 |
フルテキストURL | |
著者 |
Terao, Toshiki
Department of Hematology and Oncology, Okayama University Hospital
Kondo, Takumi
Department of Hematology and Oncology, Okayama University Hospital
Nakamura, Makoto
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Takasuka, Hiroki
Department of Hematology and Oncology, Okayama University Hospital
Fujiwara, Hideaki
Department of Hematology and Oncology, Okayama University Hospital
Asada, Noboru
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Ennishi, Daisuke
Department of Hematology and Oncology, Okayama University Hospital
Nishimori, Hisakazu
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Fujii, Keiko
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Fujii, Nobuharu
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
publons
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Maeda, Yoshinobu
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Matsuoka, Ken-Ichi
Department of Hematology and Oncology, Okayama University Hospital
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抄録 | We evaluated the clinical impacts of the concurrent modification of post-transplant cyclophosphamide (PTCy) dose and tacrolimus (Tac)-initiation timing in 61 patients with human leukocyte antigen-haploidentical transplantation. Reduced-dose PTCy (80 mg/kg) was associated with a higher incidence of moderate-to-severe chronic graft-versus-host disease (GVHD) than standard-dose PTCy (100 mg/kg) (35.0% vs. 26.6%, p = 0.053). Notably, early-initiation Tac (day -1) increased moderate-to-severe chronic GVHD than standard-initiation Tac (day 5) in the reduced-dose PTCy group (p = 0.032), whereas Tac-initiation timing did not impact chronic GVHD in the standard-dose PTCy group. These data indicate that the combination of reduced-dose PTCy and early-initiation Tac can amplify chronic GVHD.
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キーワード | chronic GVHD
haploidentical
hematopoietic stem-cell transplantation
PTCy
tacrolimus
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発行日 | 2024-06-19
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出版物タイトル |
eJHaem
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巻 | 5巻
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号 | 4号
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出版者 | Wiley
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開始ページ | 810
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終了ページ | 814
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ISSN | 2688-6146
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2024 The Author(s).
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論文のバージョン | publisher
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DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1002/jha2.962
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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Citation | Terao T, Kondo T, Nakamura M, Takasuka H, Fujiwara H, Asada N, et al. Combination of reduced post-transplant cyclophosphamide and early tacrolimus initiation increases the incidence of chronic graft-versus-host disease in human leukocyte antigen-haploidentical peripheral blood stem-cell transplantation. eJHaem. 2024; 5: 810–814. https://doi.org/10.1002/jha2.962
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