| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| フルテキストURL | 78_2_123.pdf |
| 著者 | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| 抄録 | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| キーワード | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688830 |
| Web of Science KeyUT | 001229151800004 |
| フルテキストURL | fulltext20240213-01.pdf |
|---|---|
| 著者 | Urata, Tomohiro| Naoi, Yusuke| Jiang, Aixiang| Boyle, Merrill| Sunami, Kazutaka| Imai, Toshi| Nawa, Yuichiro| Hiramatsu, Yasushi| Yamamoto, Kazuhiko| Fujii, Soichiro| Yoshida, Isao| Yano, Tomofumi| Chijimatsu, Ryota| Murakami, Hiroyuki| Ikeuchi, Kazuhiro| Kobayashi, Hiroki| Tani, Katsuma| Ujiie, Hideki| Inoue, Hirofumi| Tomida, Shuta| Yamamoto, Akira| Kondo, Takumi| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Sawada, Keisuke| Momose, Shuji| Tamaru, Jun-ichi| Nishikori, Asami| Sato, Yasuharu| Yoshino, Tadashi| Maeda, Yoshinobu| Scott, David W.| Ennishi, Daisuke| |
| 発行日 | 2023-12-14 |
| 出版物タイトル | Blood Advances |
| 巻 | 7巻 |
| 号 | 24号 |
| 出版者 | American Society of Hematology |
| 開始ページ | 7459 |
| 終了ページ | 7470 |
| ISSN | 2473-9529 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by The American Society of Hematology. |
| 論文のバージョン | publisher |
| PubMed ID | 37552496 |
| DOI | 10.1182/bloodadvances.2023010402 |
| Web of Science KeyUT | 001141306600001 |
| 関連URL | isVersionOf https://doi.org/10.1182/bloodadvances.2023010402 |
| JaLCDOI | 10.18926/AMO/65740 |
|---|---|
| フルテキストURL | 77_4_347.pdf |
| 著者 | Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki| |
| 抄録 | The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry. |
| キーワード | flow cytometry stem cell transplantation transplantation-associated microangiopathy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-08 |
| 巻 | 77巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 347 |
| 終了ページ | 357 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37635134 |
| Web of Science KeyUT | 001163659800002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ikegawa, Shuntaro| Matsuoka, Ken-ichi| |
| キーワード | regulatory T cell graft-versus-host disease interleukin 2 immune checkpoint inhibitor post-transplant cyclophosphamide |
| 発行日 | 2021-08-30 |
| 出版物タイトル | Frontiers In Immunology |
| 巻 | 12巻 |
| 出版者 | Frontiers Media SA |
| 開始ページ | 713358 |
| ISSN | 1664-3224 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Ikegawa and Matsuoka. |
| 論文のバージョン | publisher |
| PubMed ID | 34526990 |
| DOI | 10.3389/fimmu.2021.713358 |
| Web of Science KeyUT | 000698797000001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fimmu.2021.713358 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sugiura, Hiroyuki| Nishimori, Hisakazu| Nishii, Kazuya| Toji, Tomohiro| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Nakata, Koh| Kiura, Katsuyuki| Maeda, Yoshinobu| |
| キーワード | pulmonary alveolar proteinosis primary myelofibrosis autopsy ruxolitinib |
| 発行日 | 2020-08-15 |
| 出版物タイトル | Internal Medicine |
| 巻 | 59巻 |
| 号 | 16号 |
| 開始ページ | 2023 |
| 終了ページ | 2028 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by The Japanese Society of Internal Medicine |
| 論文のバージョン | publisher |
| PubMed ID | 32448830 |
| DOI | 10.2169/internalmedicine.4082-19 |
| Web of Science KeyUT | 000563078400014 |
| 関連URL | isVersionOf https://doi.org/10.2169/internalmedicine.4082-19 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Iwamuro, Masaya| Ennishi, Daisuke| Matsuoka, Ken-ichi| Tanaka, Takehiro| Okanoue, Shotaro| Obayashi, Yuka| Sakae, Hiroyuki| Kawahara, Yoshiro| Okada , Hiroyuki| |
| キーワード | desquamative esophagitis sloughing esophagitis esophagitis dissecans superficialis peripheral blood stem cell transplantation |
| 発行日 | 2020-12-01 |
| 出版物タイトル | Internal Medicine |
| 巻 | 59巻 |
| 号 | 23号 |
| 出版者 | The Japanese Society of Internal Medicine |
| 開始ページ | 3015 |
| 終了ページ | 3022 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by The Japanese Society of Internal Medicine |
| 論文のバージョン | publisher |
| PubMed ID | 32759586 |
| NAID | 130007948814 |
| DOI | 10.2169/internalmedicine.4977-20 |
| Web of Science KeyUT | 000596584400008 |
| 関連URL | isVersionOf https://doi.org/10.2169/internalmedicine.4977-20 |
| 著者 | Kobayashi, Hiroki| Asada, Noboru| Igawa, Takuro| Abe, Masaya| Meguri, Yusuke| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Nobuharu| Matsuoka, Ken-ichi| Yoshino, Tadashi| Maeda, Yoshinobu| |
|---|---|
| キーワード | adult T-cell leukemia-lymphoma breast involvement positron emission tomography/computed tomography |
| 発行日 | 2020-11-01 |
| 出版物タイトル | Internal Medicine |
| 巻 | 59巻 |
| 号 | 21号 |
| 出版者 | 日本内科学会 |
| 開始ページ | 2757 |
| 終了ページ | 2761 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by The Japanese Society of Internal Medicine |
| 論文のバージョン | publisher |
| DOI | 10.2169/internalmedicine.5077-20 |
| 関連URL | isVersionOf https://doi.org/10.2169/internalmedicine.5077-20 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Oka, Takashi| Matsuoka, Ken-Ichi| Utsunomiya, Atae| |
| キーワード | ATL HTLV-1 PDT PDD chemotherapy allogeneic hematopoietic cell transplantation immunotherapy GVHD ALA-PDT/PDD |
| 発行日 | 2020-02-02 |
| 出版物タイトル | Cancers |
| 巻 | 12巻 |
| 号 | 2号 |
| 出版者 | MDPI |
| 開始ページ | 335 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 32024297 |
| DOI | 10.3390/cancers12020335 |
| Web of Science KeyUT | 000522477300081 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers12020335 |
| JaLCDOI | 10.18926/AMO/54608 |
|---|---|
| フルテキストURL | 70_5_429.pdf |
| 著者 | Asano, Takeru| Matsuoka, Ken-ichi| Iyama, Satoshi| Ohashi, Kazuteru| Inamoto, Yoshihiro| Ohwada, Chikako| Murata, Makoto| Satake, Atsushi| Yoshida, Chikamasa| Nakase, Koichi| Mori, Yasuo| Tanimoto, Mitsune| |
| 抄録 | Chronic graft versus host disease (cGVHD) remains a major problem for long survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Currently, corticosteroid therapy is effective for cGVHD as the first line therapy. However, prolonged therapy with corticosteroids causes various severe adverse events. To develop the new therapeutic strategy of cGVHD, we have launched a multicenter phase I/IIa clinical trial of low dose subcutaneous interleukin-2 (IL-2) for treatment of steroid refractory cGVHD, which is constituted of 2 sequential phases (induction phase and maitanance phase). This study will provide the new therapeutic option for patients with refractory cGVHD after allogeneic HSCT. |
| キーワード | chronic GVHD allogeneic HSCT steroid refractory IL-2 |
| Amo Type | Clinical Study Protocols |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-10 |
| 巻 | 70巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 429 |
| 終了ページ | 433 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27777442 |
| Web of Science KeyUT | 000388098700019 |
| 著者 | Sugiyama, Haruko| Maeda, Yoshinobu| Nishimori, Hisakazu| Yamasuji, Yoshiko| Matsuoka, Ken-ichi| Fujii, Nobuharu| Kondo, Eisei| Shinagawa, Katsuji| Tanaka, Takehiro| Takeuchi, Kengo| Teshima, Takanori| Tanimoto, Mitsune| |
|---|---|
| 発行日 | 2014-02 |
| 出版物タイトル | Biology of Blood and Marrow Transplantation |
| 巻 | 20巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |