ID | 32023 |
JaLCDOI | |
フルテキストURL | |
著者 |
Sugata, Ken-ichi
Okayama University
Ogawa, Teruhiro
Okayama University
Nakashima, Tomoko
Okayama University
Sugata, Akemi
Okayama University
Kasaki, Norio
Okayama University
Gunduz, Mehmet
Okayama University
|
抄録 | The prevalence of penicillin non-susceptible Streptococcus pneumoniae (PNSSP) is increasing among isolates from acute otitis media (AOM). Repeated episodes of antibiotic exposure are a well-known risk factor for the isolation of PNSSP although otitis-prone or recurrent AOM cases frequently require repeated courses of antibiotic treatment. In order to evaluate the chronological alteration of S. pneumoniae during recurrences of AOM, strains of S. pneumoniae were isolated from 11 patients, each of whom had experienced 2-4 episodes of AOM, were examined. Every bacterial specimen obtained from a single episode of recurrent AOM was examined by PCR-based penicillin-binding protein (PBP) assay, serotyping, and amplified fragment length polymorphism (AFLP), then compared to other samples from the same case. Two cases (18.2%) showed strain diversity during repeated antibiotic treatments by serotyping or PBP-assay. By AFLP analysis, 6 cases (54.5%) demonstrated heterogeneous strains during recurrent AOM. Clonal survivors of previous episodes of AOM were not always the cause of subsequent episodes of AOM, even in otitis-prone cases. |
キーワード | acute otitis media
amplified fragment length polymorphism(AFLP)
penicillin non-susceptible Streptococcus pncumoniac.
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2001-06
|
巻 | 55巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 167
|
終了ページ | 174
|
ISSN | 0386-300X
|
NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
|
論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |