ID | 65770 |
フルテキストURL | |
著者 |
Higashionna, Tsukasa
Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
Harada, Keisaku
Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
Maruo, Akinari
Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
Niimura, Takahiro
Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School
Tan, Elizabeth
Graduate School, Centro Escolar University Manila
Vu, Quynh Thi
Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy
Kawabata, Takayoshi
Department of Pharmacy, Okayama University Hospital
Ushio, Soichiro
Department of Pharmacy, Okayama University Hospital
Hamano, Hirofumi
Department of Pharmacy, Okayama University Hospital
Kajizono, Makoto
Department of Pharmacy, Okayama University Hospital
Zamami, Yoshito
Department of Pharmacy, Kitakyushu City Yahata Hospital
Ishizawa, Keisuke
Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School
Harada, Ko
Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel
Hinotsu, Shiro
Department of Biostatistics and Data Management, Sapporo Medical University
Kano, Mitsunobu R.
Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Hagiya, Hideharu
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
researchmap
Koyama, Toshihiro
Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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抄録 | Simple Summary The number of cases of head and neck cancer (HNC) and related deaths has recently increased worldwide. To the best of our knowledge, few studies have examined crude or age-adjusted HNC mortality rates in Japan. Therefore, this study aimed to determine the trends in crude and age-adjusted mortality rates for HNC per million individuals in Japan from 1999 to 2019. In Japan, the number of HNC-related deaths increased 1.48-fold. Age-adjusted mortality rates for HNC were four times higher in men than in women, and the rates for both men and women decreased over the 21-year period. This study clarifies the changes in age-adjusted mortality rates of HNC in Japan over time and will aid in developing targeted screening and prevention programs for HNC. Globally, the numbers of head and neck cancer (HNC) cases and related deaths have recently increased. In Japan, few studies have examined crude or age-adjusted HNC mortality rates. Therefore, this study aimed to determine the trends in crude and age-adjusted mortality rates for HNC per million individuals in Japan from 1999 to 2019. Data on HNC-associated deaths were extracted from the national death certificate database using the International Classification of Diseases, Tenth Revision (n = 156,742). HNC mortality trends were analysed using joinpoint regression models to estimate annual percentage change (APC) and average APC (AAPC). Among men, no significant change was observed in the age-adjusted death rate trend from 1999 to 2014; however, a marked decrease was observed from 2014 to 2019. No changing point was observed in women. Age-adjusted mortality rates continuously decreased over the 21-year period, with an AAPC of -0.7% in men and -0.6% in women. In conclusion, the overall trend in age-adjusted rates of HNC-associated deaths decreased, particularly among men, in the past 5 years. These results will contribute to the formulation of medical policies to develop targeted screening and prevention programmes for HNC in Japan and determine the direction of treatment strategies.
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キーワード | head and neck cancer
mortality
joinpoint regression
trend analysis
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発行日 | 2023-07-26
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出版物タイトル |
Cancers
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巻 | 15巻
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号 | 15号
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出版者 | MDPI
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開始ページ | 3786
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ISSN | 2072-6694
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2023 by the authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/cancers15153786
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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Citation | Higashionna, T.; Harada, K.; Maruo, A.; Niimura, T.; Tan, E.; Vu, Q.T.; Kawabata, T.; Ushio, S.; Hamano, H.; Kajizono, M.; et al. Trends in Head and Neck Cancer Mortality from 1999 to 2019 in Japan: An Observational Analysis. Cancers 2023, 15, 3786. https://doi.org/10.3390/cancers15153786
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助成機関名 |
Japan Society for the Promotion of Science
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助成番号 | 22K10415
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