ID | 32287 |
JaLCDOI | |
フルテキストURL | |
著者 |
Shibahara, Motomi
Okayama University
Asahara, Hiroshi
Okayama University
Yoshikawa, Takeshi
Okayama University
Mitani, Shigeru
Okayama University
Kondo, Yoichi
Okayama University
Inoue, Hajime
Okayama University
|
抄録 | We investigated the presence of osteocyte apoptosis in the necrotic trabeculae of the femoral head of spontaneously hypertensive rat (SHR) using the in situ nick end labeling (TUNEL) method and transmission electron microscopy. The occurrence of osteonecrosis and ossification disturbance was significantly higher in SHR compared with Wistar Kyoto (WKY) rats, and Wistar (WT) rats used as control animals (P < 0.01). A high population of TUNEL positive osteocytes was detected mainly in 10- and 15-week-old SHRs. Sectioned examination of the femoral head of SHRs and WKY rats by electron microscopy revealed apoptotic cell appearances such as aggregation of chromatin particles and lipid formation. In contrast, a positive reaction was significantly lower in osteocytes in the femoral heads of WT rats (P < 0.01). Our results indicate that apoptosis forms an important component of the global pathologic process affecting the femoral head of SHR, which leads to osteonecrosis in this region. |
キーワード | apoptosis
spontaneously hypertensive rat
osteonecrosis of the femoral head
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2000-04
|
巻 | 54巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 67
|
終了ページ | 74
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
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言語 |
英語
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論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |