Association of elevated plasma B-type natriuretic peptide levels with paroxysmal atrial fibrillation in patients with nonobstructive hypertrophic cardiomyopathy

Matsuura, Hiroko; Murakami, Takashi; Hina, Kazuyoshi; Yamamoto, Keizo; Kawamura, Hiroshi; Sogo, Taiji; Shinohata, Ryoko; Usui, Shinichi; Ninomiya, Yoshifumi; Kusachi, Shozo

doi:10.1016/j.clinbiochem.2007.10.015

Permalink : https://ousar.lib.okayama-u.ac.jp/34232

ID	34232
フルテキストURL	Fulltext.pdf 222 KB fig_1_1.tiff 554 KB fig_1_2.tiff 572 KB
著者	Matsuura, Hiroko Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Murakami, Takashi Department of Cardiology, Cardiovascular Center, Sakakibara Hospital Kaken ID publons Hina, Kazuyoshi Department of Cardiology, Cardiovascular Center, Sakakibara Hospital Yamamoto, Keizo Department of Cardiology, Cardiovascular Center, Sakakibara Hospital Kawamura, Hiroshi Department of Cardiology, Cardiovascular Center, Sakakibara Hospital Sogo, Taiji Department of Cardiovascular Medicine, Takamatsu Red Cross Hospital Shinohata, Ryoko Department of Medical Technology, Okayama University Graduate School of Health Sciences Kaken ID publons researchmap Usui, Shinichi Department of Medical Technology, Okayama University Graduate School of Health Sciences Kaken ID publons researchmap Ninomiya, Yoshifumi Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons Kusachi, Shozo Department of Medical Technology, Okayama University Graduate School of Health Sciences
抄録	Objectives: To investigate the relationship between the plasma B-type natriuretic peptide (BNP) level and the occurrence of atrial fibrillation (AF) in nonobstructive hypertrophic cardiomyopathy (HCM) patients. Methods: Patients (n=97) were classified into chronic AF (CAF; n=14), paroxysmal AF (PAF; n=18) and normal sinus rhythm (NSR; n=65) groups. The plasma BNP values were analyzed with logarithmic transformation. Results: The PAF group showed significantly higher plasma BNP levels than the NSR group [mean (range; -1 SD and +1 SD); 248.3 (143.5, 429.5) vs. 78.2 (27.9, 218.8 ng/L), p<0.0001]. The CAF group also showed significantly higher plasma BNP levels than the NSR group [291.1 (161.4, 524.8 ng/L), p<0.0001]. Multivariate analysis with other clinical factors selected association of PAF as one of the factors that increased the plasma BNP level. Conclusions: The present study indicated that plasma BNP level is clinically useful for identification of nonobstructive HCM patients who have a risk of PAF.
キーワード	clinical study cardiomyopathy tachyarrhythmia enzyme immunoassay peptide sensitivity and specificity
備考	Published with permission from the copyright holder. This is a author's copy,as published in Clinical Biochemistry , 2008 Vol.41 Issue.3 pp.134-139 Publisher URL: http://dx.doi.org/10.1016/j.clinbiochem.2007.10.015 Direct access to Thomson Web of Science record Copyright © The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
発行日	2008-02
出版物タイトル	Clinical Biochemistry
巻	41巻
号	3号
出版者	Elsevier Inc.
開始ページ	134
終了ページ	139
ISSN	0009-9120
NCID	AA00607603
資料タイプ	学術雑誌論文
言語	英語
著作権者	The Canadian Society of Clinical Chemists. Published by Elsevier Inc.
論文のバージョン	author
査読	有り
DOI	10.1016/j.clinbiochem.2007.10.015
PubMed ID	18039472
Web of Science KeyUT	000253178700004
Submission Path	biochemistry/12