ID | 33023 |
フルテキストURL | |
著者 |
Katsu, Takashi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Tsunamoto, Yumi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hanioka, Nobumitsu
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kaken ID
publons
researchmap
Komagoe, Keiko
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Masuda, Kazufumi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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抄録 | S,S,S-Tris(2-ethylhexyl) phosphorotrithioate proved to be an effective solvent mediator for constructing a mexiletine-sensitive membrane electrode in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. Among a series of phosphorus compounds containing phosphoryl (P=O) groups, this solvent mediator showed the highest sensitivity to mexiletine in phosphate-buffered physiological saline containing 0.15 mol L-1 NaCl and 0.01 mol L-1 NaH2PO4/Na2HPO4 (pH 7.4), giving a detection limit of 2 x 10(-6) mol L-1 with a slope of 58.8 mV decade(-1). This is the best reported detection limit of any mexiletine-sensitive electrode developed to date. Owing to its high selectivity toward inorganic cations, the electrode was used to determine the level of mexiletine in saliva, the monitoring of which is quite effective for controlling the dose of this drug noninvasively. The mexiletine concentrations determined with the mexiletine-sensitive electrode compared favorably with those determined by high-performance liquid chromatography.
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キーワード | Ion-selective electrode
Mexiletine determination
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate
Solvent mediator
Drug monitoring
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備考 | Published with permission from the copyright holder.
This is published in Analytical and Bioanalytical Chemistry, 2007 Vol.387 Issue.6 pp.2057-2064 Publisher URL: http://dx.doi.org/10.1007/s00216-006-1105-y Direct access to Thomson Web of Science record (C)2007 Springer-Verlag. |
発行日 | 2007-03
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出版物タイトル |
Analytical and Bioanalytical Chemistry
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巻 | 387巻
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号 | 6号
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出版者 | Springer Berlin / Heidelberg
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開始ページ | 2057
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終了ページ | 2064
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ISSN | 1618-2642
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NCID | AA00524787
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | Springer-Verlag
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT | |
Submission Path | analytical_chemistry/42
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