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ID 63091
フルテキストURL
著者
Tsuge, Mitsuru Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Ikeda, Masanori Department of Pediatrics, Okayama University Hospital Kaken ID publons researchmap
Kondo, Yoichi Department of Pediatrics, Matsuyama Red Cross Hospital
Tsukahara, Hirokazu Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
抄録
Omalizumab is used for the treatment of persistent severe allergic asthma in adults and children. However, some patients remain symptomatic even after omalizumab treatment. In bronchial asthma, chronic inflammation of the bronchial wall causes thickening of the airway wall, resulting from irreversible airway remodeling. Progression of airway remodeling causes airflow obstruction, leading to treatment resistance. We report three Japanese children with severe asthma who had a poor response to omalizumab treatment. They had a long period of inadequate management of asthma before initiating omalizumab. Even after omalizumab treatment, their symptoms persisted, and the parameters of spirometry tests did not improve. We hypothesized that omalizumab was less effective in these patients because airway wall remodeling had already progressed. We retrospectively evaluated the bronchial wall thickness using a three-dimensional bronchial wall analysis with chest computed tomography. The bronchial wall thickness was increased in these cases compared with six responders. Progressed airway wall thickness caused by airway remodeling may be associated with a poor response to omalizumab in children with severe asthma.
キーワード
Bronchial asthma
omalizumab
bronchial wall thickness
child
computed tomography
airway
発行日
2022-01-07
出版物タイトル
Journal Of International Medical Research
50巻
1号
出版者
Sage Publications Ltd
開始ページ
03000605211070492
ISSN
0300-0605
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
著作権者
© The Author(s) 2022
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1177/03000605211070492
ライセンス
https://creativecommons.org/licenses/by-nc/4.0/
Citation
Tsuge M, Ikeda M, Kondo Y, Tsukahara H. Severe pediatric asthma with a poor response to omalizumab: a report of three cases and three-dimensional bronchial wall analysis. Journal of International Medical Research. January 2022. doi:10.1177/03000605211070492