ID | 53137 |
フルテキストURL | |
著者 |
Mizuki, Yutaka
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Takaki, Manabu
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Kaken ID
publons
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Okahisa, Yuko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Kaken ID
researchmap
Sakamoto, Shinji
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Kodama, Masafumi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Ujike, Hiroshi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Uchitomi, Yosuke
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
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抄録 | ObjectiveThe human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene is one of the candidate genes for type 2 diabetes mellitus (T2DM). ARHGEF11 is mapped to chromosome 1q21, which has susceptible risk loci for T2DM and schizophrenia. We hypothesized that ARHGEF11 contributes to the pathogenesis of schizophrenia.
MethodWe selected eight single nucleotide polymorphisms of ARHGEF11 that had significant associations with T2DM for a case-control association study of 490 patients with schizophrenia and 500 age-matched and sex-matched controls.
ResultsWe did not find any differences in allelic, genotypic associations, or minor allele frequencies with schizophrenia. Analysis of the rs6427340-rs6427339 haplotype and the rs822585-rs6427340-rs6427339 haplotype combination provided significant evidence of an association with schizophrenia (global permutations p=0.00047 and 0.0032, respectively). C-C of the rs6427340-rs6427339 haplotype and A-C-C of the rs822585-rs6427340-rs6427339 haplotype carried higher risk factors for schizophrenia (permutation p=0.0010 and 0.0018, respectively). A-C-T of the rs822585-rs6427340-rs6427339 haplotype had a possible protective effect (permutation p=0.031).
ConclusionThese results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia.
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キーワード | ARHGEF11
case-control study
schizophrenia
type 2 diabetes mellitus
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備考 | This is the accepted version of the following article: FULLCITE, which has been published in final form at http://dx.doi.org/10.1002/hup.2435
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発行日 | 2014-11
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出版物タイトル |
Human Psychopharmacology: Clinical and Experimental
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巻 | 29巻
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号 | 6号
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開始ページ | 552
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終了ページ | 558
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資料タイプ |
学術雑誌論文
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53126
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言語 |
英語
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著作権者 | © 2014 John Wiley & Sons, Ltd.
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論文のバージョン | author
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査読 |
有り
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DOI |