| タイトル（別表記） | Inhibitory effects of caffeine on allergic rhinitis symptoms in mice |
|---|---|
| フルテキストURL | poalas_033_018_021.pdf |
| 著者 | 辻本 まどか| 佐伯 綾希子| 鈴木 真奈美| 白神 俊幸| 杉本 幸雄| 林 泰資| |
| 抄録 | We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 18 |
| 終了ページ | 21 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| 著者 | Ishimoto, Hidekazu| Shibata, Mari| Myojin, Yuki| Ito, Hideyuki| Sugimoto, Yukio| Tai, Akihiro| Hatano, Tsutomu| |
|---|---|
| 発行日 | 2011-10-01 |
| 出版物タイトル | Bioorganic & Medicinal Chemistry Letters |
| 巻 | 21巻 |
| 号 | 19号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/31623 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Sugimoto, Yukio| Iba, Yoshionori| Ishizawa, Keisuke| Suzuki, Genzo| Kamei, Chiaki| |
| 抄録 | The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release. |
| キーワード | levocabastine guinea pig lung fragment lipid mediator |
| Amo Type | Brief Note |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 1999-12 |
| 巻 | 53巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 271 |
| 終了ページ | 274 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 10631382 |
| Web of Science KeyUT | 000084414300005 |
| 著者 | 杉本 幸雄| |
|---|---|
| 発行日 | 2003-09 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 20巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 杉本 幸雄| |
|---|---|
| 発行日 | 1998-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |