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ID 63040
フルテキストURL
著者
Suzuki, Etsuji Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID publons researchmap
Yamamoto, Eiji Okayama University of Science
抄録
For decades, the sufficient cause model and the counterfactual model have shaped our understanding of causation in biomedical science, and the link between these two models has enabled us to obtain a deeper understanding of causality. Recently, a new causal model—the marginal sufficient component cause model—was proposed and applied in the context of interaction or mediation. The proponents of this model have emphasized its utility in visualizing the presence of “agonism” (a subtype of mechanistic interaction) in the counterfactual framework, claiming that the concept of agonism has not been clearly defined in causal inference and that agonistic interaction cannot be visualized by the conventional sufficient cause model. In this article, we illustrate that careful scrutiny based on the conventional sufficient cause model yields further insights into the concept of agonism in a more biologic sense. We primarily focus on the following three points: a) “agonism” defined in the counterfactual model can be visualized as sets of sufficient causes in the conventional sufficient cause model; b) although the so-called independent competing assumption or no redundancy assumption may seem irrelevant in the marginal sufficient component cause model, researchers do need to assume that potential completion times of relevant marginal sufficient causes differ; c) possibly differing potential completion times of marginal sufficient causes cannot be discerned until their hidden mechanistic paths are considered in the conventional sufficient cause model. In this rapidly progressing field of research, decades after its introduction, the sufficient cause model retains its worth.
キーワード
Agonism
Causality
Counterfactual model
Mediation
Potential outcomes
Sufficient cause model
備考
This is a non-final version of an article published in final form in Suzuki, Etsuji; Yamamoto, Eiji Marginal Sufficient Component Cause Model, Epidemiology: November 2021 - Volume 32 - Issue 6 - p 838-845 doi: 10.1097/EDE.0000000000001411
発行日
2021-11
出版物タイトル
Epidemiology
32巻
6号
出版者
Ovid Technologies (Wolters Kluwer Health)
開始ページ
838
終了ページ
845
ISSN
1044-3983
NCID
AA10832184
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
著作権者
Copyright © 2021 Wolters Kluwer Health, Inc
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1097/ede.0000000000001411
Citation
Suzuki, Etsuji; Yamamoto, Eiji Marginal, Sufficient Component Cause Model, Epidemiology: November 2021 - Volume 32 - Issue 6 - p 838-845 doi: 10.1097/EDE.0000000000001411
助成機関名
Japan Society for the Promotion of Science
助成番号
JP20K10471
JP18K10104
JP20K10499