ID | 31556 |
JaLCDOI | |
フルテキストURL | |
著者 |
Ota, Kosuke
Okayama University
Ota, Zensuke
Okayama University
Makino, Hirofumi
Okayama Uniiversity
|
抄録 | In order to clarify the mechanism of proteinuria in diabetic nephropathy, ultrastructural changes of the glomerular basement membrane (GBM) in patients with diabetic nephropathy were examined by electron microscopy using our newly devised "tissue negative staining method". The normal human GBM showed a fine meshwork structure consisting of fibrils forming the small pores. The diameter of these pores was slightly smaller than that of human albumin molecules. The GBM in patients with diabetic nephropathy showed irregular thickening. At higher magnification, hitherto unknown cavities and tunnel structures, which were not seen in normal controls, were observed in the thickened GBM. In some portions, these cavities presented a honeycomb-like appearance. The diameters of the cavities and tunnels were far larger than the dimensions of albumin molecules. These enlarged structures are believed to allow serum protein molecules to pass through the GBM from the capillary lumen to the urinary space. These results suggest that the cause of massive proteinuria in diabetic nephropathy is the disruption of the size barrier of the GBM. |
キーワード | glomerular basement membrane
diabetic nephropathy
tissue negative staining
nephrotic syndrome
ultrastructure
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1993-08
|
巻 | 47巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 267
|
終了ページ | 272
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
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論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |