ID | 66986 |
フルテキストURL | |
著者 |
Oyama, Atsushi
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
Takaki, Akinobu
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
Kaken ID
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Adachi, Takuya
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
Wada, Nozomu
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
Takeuchi, Yasuto
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
Onishi, Hideki
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
Shiraha, Hidenori
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
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Okada, Hiroyuki
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
Kaken ID
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Otsuka, Motoyuki
Department of Gastroenterology and Hepatology, Okayama University, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences
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抄録 | Background/purpose Primary sclerosing cholangitis (PSC) is a rare chronic liver disease. The mechanisms and prediction of PSC progression are unclear. Recent investigations have shown that general conditions, such as oxidative stress, affect the course of chronic diseases. We investigated the clinical course and oxidative stress-related condition of PSC to determine prognostic factors.
Methods We recruited 58 patients with PSC (mean age; 37.4 years, mean observation period; 1382 days) who visited our department from 2003 to 2021. Clinical characteristics were investigated to define prognostic factors. Oxidative stress status was evaluated using two types of markers: an oxidative stress marker (serum reactive oxygen metabolite; dROM) and an antioxidant marker (serum OXY adsorbent test; OXY). Results The revised Mayo risk, Child–Pugh, model for end-stage liver disease-sodium (MELD-Na) scores or fibrosis-related FIB-4 index significantly predicted poor overall survival. High intestinal immunoglobulin A (IgA) levels predicted poor survival. Among patients with high and intermediate revised Mayo risk scores, those with physiologically high dROM levels showed better survival than those with lower dROM levels. In this population, dROM was negatively correlated with AST and IgA, which are both correlated with survival. Conclusions High and intermediate revised Mayo risk score group predicted a poor clinical course in PSC. Additionally, the Child–Pugh score, MELD-Na score, FIB-4 index, and serum IgA were significantly correlated with survival. In patients with high and intermediate revised Mayo risk scores, physiologically high oxidative stress status correlated with low IgA levels and a good prognosis. |
キーワード | Primary sclerosing cholangitis
Oxidative stress marker
Prognosis
Serum reactive oxygen metabolite
Total serum antioxidant capacity
Revised Mayo risk score
Child–Pugh score
MELD score
FIB-4 index
Serum dROM
Serum OXY-adsorbent test
Immunoglobulin A
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備考 | The version of record of this article, first published in Hepatology International, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12072-023-10557-2
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発行日 | 2023-07-26
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出版物タイトル |
Hepatology International
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巻 | 17巻
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号 | 5号
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出版者 | Springer Science and Business Media LLC
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開始ページ | 1215
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終了ページ | 1224
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ISSN | 1936-0533
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2023
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1007/s12072-023-10557-2
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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Citation | Oyama, A., Takaki, A., Adachi, T. et al. Oxidative stress-related markers as prognostic factors for patients with primary sclerosing cholangitis in Japan. Hepatol Int 17, 1215–1224 (2023). https://doi.org/10.1007/s12072-023-10557-2
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助成機関名 |
Okayama University
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