ID | 63504 |
フルテキストURL | |
著者 |
Kobayashi, Aoshi
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Hamada, Mayuko
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
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Yoshida, Masa-aki
Oki Marine Biological Station, Shimane University
Kobayashi, Yasuhisa
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Tsutsui, Naoaki
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Sekiguchi, Toshio
Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University
Matsukawa, Yuta
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Maejima, Sho
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Gingell, Joseph J.
Vertex Pharmaceuticals (Europe) Ltd.
Sekiguchi, Shoko
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Hamamoto, Ayumu
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Hay, Debbie L.
School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland
Morris, John F.
Department of Physiology, Anatomy, and Genetic, Le Gros Clark Building, University of Oxford
Sakamoto, Tatsuya
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
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Sakamoto, Hirotaka
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado
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抄録 | Vasopressin/oxytocin (VP/OT)–related peptides are essential for mammalian antidiuresis, sociosexual behavior, and reproduction. However, the evolutionary origin of this peptide system is still uncertain. Here, we identify orthologous genes to those for VP/OT in Platyhelminthes, intertidal planarians that have a simple bilaterian body structure but lack a coelom and body-fluid circulatory system. We report a comprehensive characterization of the neuropeptide derived from this VP/OT-type gene, identifying its functional receptor, and name it the “platytocin” system. Our experiments with these euryhaline planarians, living where environmental salinities fluctuate due to evaporation and rainfall, suggest that platytocin functions as an “antidiuretic hormone” and also organizes diverse actions including reproduction and chemosensory-associated behavior. We propose that bilaterians acquired physiological adaptations to amphibious lives by such regulation of the body fluids. This neuropeptide-secreting system clearly became indispensable for life even without the development of a vascular circulatory system or relevant synapses.
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発行日 | 2022-3-4
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出版物タイトル |
Science Advances
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巻 | 8巻
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号 | 9号
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出版者 | American Association for the Advancement of Science (AAAS)
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開始ページ | eabk0331
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ISSN | 2375-2548
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | Copyright © 2022 The Authors, some rights reserved
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
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関連URL | isVersionOf https://doi.org/10.1126/sciadv.abk0331
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ライセンス | https://creativecommons.org/licenses/by-nc/4.0/
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助成機関名 |
Japan Society for the Promotion of Science
Ministry of Education, Culture, Sports, Science and Technology
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助成番号 | 15K15202
15H05724
15KK025708
16H06280
21H02520
21H00428
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