ID | 32101 |
JaLCDOI | |
フルテキストURL | |
著者 |
Zhang, Shan
Okayama University
Hagioka, Shingo
Okayama University
Morita, Kiyoshi
Okayama University
|
抄録 | To elucidate the mechanism by which hyperbaric oxygen (HBO2) induces electrical discharge, changes in the extracellular concentrations of GABA and glutamate were measured every 5 min using a microdialysis technique in rats during a period of exposure to HBO2 (5 atm abs). Electrical discharge was observed at 28 +/- 4 min after the onset of exposure. Though the extracellular concentrations of glutamate remained unchanged, the extracellular GABA concentrations (pre-exposure level, 0.026 +/- 0.005 microM in dialysate) began to decrease 15 min after the onset of exposure and reached their lowest level (74 +/- 14%, 0.019 +/- 0.004 microM) at the time of appearance of the discharge. There was a close logistic relationship between extracellular GABA concentrations and the discharge incidence, and the extracellular concentrations of GABA causing electrical discharge in 50% of the animals were estimated to be 80% of the pre-exposure level. These results suggest a possible mechanism that HBO2 exposure-induced discharge is caused by the decrease in extracellular concentration of GABA. |
キーワード | glutamic acid
hyperbaric oxygenation
gamma-aminobutyricacid
microdialysis
seizures
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2004-04
|
巻 | 58巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 91
|
終了ページ | 95
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |