ID | 31973 |
JaLCDOI | |
フルテキストURL | |
著者 |
Edamura, Kohei
Okayama University
Saika, Takashi
Okayama University
Senoh, Takashi
Okayama University
Koizumi, Fumihito
Okayama University
Manabe, Daisuke
Okayama University
Ebara, Shin
Okayama University
Yokoyama, Teruhiko
Okayama University
Abarzua, Fernando
Okayama University
Nagai, Atsushi
Okayama University
Tsushima, Tomoyasu
Okayama University
|
抄録 | This study was undertaken to reveal the trends of prostate cancer and the outcome of treatment modalities for each disease stage in patients in a single institute over a 10-year period. From January 1994 through December 2003, 420 consecutive patients with previously untreated and histologically confirmed prostate cancer were analyzed for annual distributions of disease stages and treatment modalities and for long-term clinical progression-free survival, prostate cancer-specific survival, and prostate-specific antigen (PSA) failure-free survival rates for each stage and treatment modality. Annual trends showed that the number of patients, especially those with clinically localized cancer, increased dramatically. The 5-year disease-specific survival rates for patients with clinically localized disease were 100 percent for all treatment modalities, including hormonal therapy alone. Patients with PSA levels less than 10 ng/ml showed an 81 percent 5-year PSA failure-free survival rate with radical prostatectomy. Stage C patients treated by surgery or radiation-based therapy with concomitant hormonal therapy obtained 93 percent and 100 percent cause-specific survival rates, respectively, and those treated by hormonal therapy alone showed a 79 percent rate. The number of patients with localized prostate cancer was increasing in this decade. While long-term hormonal therapy alone was highly efficient in controlling localized prostate cancer, radical therapies in conjunction with neo-adjuvant hormonal therapy produced better survival rates in cases of locally advanced disease. |
キーワード | prostate carcinoma
long-term
cohort
retrospective
outcome
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2005-10
|
巻 | 59巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 195
|
終了ページ | 199
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |