ID | 64143 |
フルテキストURL | |
著者 |
Takamura, Hiroyoshi
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
ORCID
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Sugitani, Yuki
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Morishita, Ryohei
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kadota, Isao
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kaken ID
publons
researchmap
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抄録 | The first total synthesis of scabrolide F, a norcembranolide isolated from the soft coral Sinularia scabra, is described. Hydroxycarboxylic acid, which is the key synthetic intermediate, was synthesized in a convergent manner by fragment coupling. The obtained hydroxycarboxylic acid was subjected to macrolactonization and subsequent transannular ring-closing metathesis (RCM) to furnish scabrolide F. The synthetic protocol can be extended to the total synthesis of other norcembranolides.
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備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://doi.org/10.1021/acs.orglett.2c03263].
This full-text file will be available in Oct. 2023.
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発行日 | 2022-10-20
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出版物タイトル |
Organic Letters
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巻 | 24巻
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号 | 42号
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出版者 | American Chemical Society (ACS)
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開始ページ | 7845
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終了ページ | 7849
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ISSN | 1523-7060
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NCID | AA11347843
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2022 American Chemical Society
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論文のバージョン | author
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PubMed ID | |
DOI | |
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関連URL | isVersionOf https://doi.org/10.1021/acs.orglett.2c03263
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助成機関名 |
Japan Society for the Promotion of Science
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助成番号 | JP21H01938
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