このエントリーをはてなブックマークに追加
ID 56663
フルテキストURL
著者
Takamura, Hiroyoshi Department of Chemistry, Graduate School of Natural Science and Technology , Okayama University ORCID Kaken ID publons researchmap
Kikuchi, Takahiro Department of Chemistry, Graduate School of Natural Science and Technology , Okayama University
Iwamoto, Kohei Department of Chemistry, Graduate School of Natural Science and Technology , Okayama University
Nakao, Eiji Department of Chemistry, Graduate School of Natural Science and Technology , Okayama University
Harada, Naoki Department of Chemistry, Graduate School of Natural Science and Technology , Okayama University
Otsu, Taichi Department of Chemistry, Graduate School of Natural Science and Technology , Okayama University
Endo, Noriyuki Himeji EcoTech Co., Ltd.
Fukuda, Yuji Himeji EcoTech Co., Ltd.
Ohno, Osamu Department of Chemistry and Life Science, School of Advanced Engineering , Kogakuin University
Suenaga, Kiyotake Department of Chemistry, Faculty of Science and Technology , Keio University
Guo, Yue-Wei Shanghai Institute of Materia Medica , Chinese Academy of Sciences
Kadota, Isao Department of Chemistry, Graduate School of Natural Science and Technology , Okayama University Kaken ID publons researchmap
抄録
Sarcophytonolides are cembranolide diterpenes isolated from the soft corals of genus Sarcophyton. Unified total synthesis of sarcophytonolides C, E, F, G, H, and J and isosarcophytonolide D was achieved. The synthetic routes feature NaHMDS- or SmI2-mediated fragment coupling, alkoxycarbonylallylation, macrolactonization, and transannular ring-closing metathesis. These total syntheses led to the absolute configurational confirmation of sarcophytonolide H, elucidation of sarcophytonolides C, E, F, and G, and revision of sarcophytonolide J and isosarcophytonolide D. We also evaluated the antifouling activity and toxicity of the synthetic sarcophytonolides H and J and their analogues as well as the cytotoxicity of the synthetic sarcophytonolides and the key synthetic intermediates.
備考
This is an Accepted Manuscript of an article published by American Chemical Society
発行日
2018-08-09
出版物タイトル
The Journal of Organic Chemistry
83巻
18号
出版者
American Chemical Society
開始ページ
11028
終了ページ
11056
ISSN
0022-3263
NCID
AA00704100
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1021/acs.joc.8b01634