ID | 32009 |
JaLCDOI | |
フルテキストURL | |
著者 |
Ohke, Masashi
Okayama University
Tada, Shinya
Okayama University
Nabe, Makoto
Okayama University
Matsuo, Kiyoshi
Okayama University
Harada, Mine
Okayama University
|
抄録 | Allergic and chronic inflammation of the airway is regarded as the main pathogenesis of bronchial asthma, in which adhesion of inflammatory cells requires the expression of adhesion molecules. Thus, to clarify the role of fibronectin (FN) in the airway inflammation of bronchial asthma, FN levels in plasma and bronchoalveolar lavage fluid (BALF) from bronchial asthmatics were determined. FN concentrations in plasma and BALF were measured by enzyme-linked immunosorvent assay (ELISA) in 17 asthmatic patients and 10 healthy controls to elucidate the role of FN in allergic inflammation. The mean FN/albumin (Alb) level in the BALF of asthmatic patients was 2.973 micrograms/mg, which was significantly higher than that of healthy controls (0.727 microgram/mg). Non-atopic asthmatics showed a significantly higher level of FN in their BALF in comparison with atopic asthmatics, although the ratio of FN to albumin showed no significant difference. FN levels in BALF correlated significantly with total cell density (r = 0.71, P < 0.05) and alveolar macrophage density (r = 0.64, P < 0.05). FN levels in plasma did not correlate with those in BALF. In conclusion, increased FN in BALF, which was produced locally in the airways of asthmatic patients, is actively involved in the regulation of allergic inflammation. |
キーワード | airway inflammation
adhesion molecule
bronchoalveolar lavage fluid
bronchial asthma
fibronectin
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2001-04
|
巻 | 55巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 83
|
終了ページ | 89
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |