團迫浩方

Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity

フルテキストURL	fulltext20250213-02.pdf suppl20250213-02.pdf
著者	Mukohara, Fumiaki\| Iwata, Kazuma\| Ishino, Takamasa\| Inozume, Takashi\| Nagasaki, Joji\| Ueda, Youki\| Suzawa, Ken\| Ueno, Toshihide\| Ikeda, Hideki\| Kawase, Katsushige\| Saeki, Yuka\| Kawashima, Shusuke\| Yamashita, Kazuo\| Kawahara, Yu\| Nakamura, Yasuhiro\| Honobe-Tabuchi, Akiko\| Watanabe, Hiroko\| Dansako, Hiromichi\| Kawamura, Tatsuyoshi\| Suzuki, Yutaka\| Honda, Hiroaki\| Mano, Hiroyuki\| Toyooka, Shinichi\| Kawazu, Masahito\| Togashi, Yosuke\|
キーワード	cancer immunology somatic mutation T cell tumor-infiltrating lymphocytes
備考	This is an Accepted Manuscript of an article published by Proceedings of the National Academy of Sciences.\| This fulltext file will be available in Feb. 2025.\|
発行日	2024-08-21
出版物タイトル	Proceedings of the National Academy of Sciences
巻	121巻
号	35号
出版者	Proceedings of the National Academy of Sciences
開始ページ	e2320189121
ISSN	0027-8424
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 the Author(s).
論文のバージョン	author
PubMed ID	39167601
DOI	10.1073/pnas.2320189121
Web of Science KeyUT	001408603100001
関連URL	isVersionOf https://doi.org/10.1073/pnas.2320189121

Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment

フルテキストURL	fulltext20240226-03.pdf
著者	Zhou, Wenhao\| Kawashima, Shusuke\| Ishino, Takamasa\| Kawase, Katsushige\| Ueda, Youki\| Yamashita, Kazuo\| Watanabe, Tomofumi\| Kawazu, Masahito\| Dansako, Hiromichi\| Suzuki, Yutaka\| Nishikawa, Hiroyoshi\| Inozume, Takashi\| Nagasaki, Joji\| Togashi, Yosuke\|
キーワード	cancer immunology follicular helper T cell cytotoxic CD4+ T cell CXCL13 T cell exhaustion stem-like progenitor exhaustion terminally differentiated exhaustion PD-1 LAG-3 TCF1
備考	Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8+ T cells, induces CD4+ follicular helper T (TFH) cell infiltration, contributing to anti-tumor immunity. Furthermore, a part of the TFH cells in the TME exhibits cytotoxicity and directly attacks major histocompatibility complex-II-expressing tumors. TFH-like cytotoxic CD4+ T cells have high LAG-3/BLIMP1 and low TCF1 expression without self-renewal ability, whereas non-cytotoxic TFH cells express low LAG-3/BLIMP1 and high TCF1 with self-renewal ability, closely resembling the relationship between terminally differentiated and stem-like progenitor exhaustion in CD8+ T cells, respectively. Our findings provide deep insights into TFH-like CD4+ T cell exhaustion with helper progenitor and cytotoxic differentiated functions, mediating anti-tumor immunity orchestrally with CD8+ T cells.\|
発行日	2024-02-27
出版物タイトル	Cell Reports
巻	43巻
号	2号
出版者	Elsevier BV
開始ページ	113797
ISSN	2211-1247
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Author(s).
論文のバージョン	publisher
PubMed ID	38363680
DOI	10.1016/j.celrep.2024.113797
Web of Science KeyUT	001185865700001
関連URL	isVersionOf https://doi.org/10.1016/j.celrep.2024.113797

Hepatitis C virus NS5B triggers an MDA5-mediated innate immune response by producing dsRNA without the replication of viral genomes

フルテキストURL	fulltext20231110-01.pdf
著者	Dansako, Hiromichi\| Ikeda, Masanori\| Ariumi, Yasuo\| Togashi, Yosuke\| Kato, Nobuyuki\|
キーワード	double-stranded RNA hepatitis C virus innate immunity RIG-I-like receptor RNA virus
備考	This is the accepted version of the following article: Dansako, H., Ikeda, M., Ariumi, Y., Togashi, Y. and Kato, N. (2024), Hepatitis C virus NS5B triggers an MDA5-mediated innate immune response by producing dsRNA without the replication of viral genomes. FEBS J, 291: 1119-1130. https://doi.org/10.1111/febs.16980, which has been published in final form at https://doi.org/10.1111/febs.16980\| This fulltext file will be available in Oct. 2024.\|
発行日	2023-10-20
出版物タイトル	The FEBS Journal
巻	291巻
号	6号
出版者	Wiley
開始ページ	1119
終了ページ	1130
ISSN	1742-464X
NCID	AA11998513
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Federation of European Biochemical Societies.
論文のバージョン	author
PubMed ID	37863517
DOI	10.1111/febs.16980
Web of Science KeyUT	001091349500001
関連URL	isVersionOf https://doi.org/10.1111/febs.16980

Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies

フルテキストURL	fulltext20231004-03.pdf fig1_20231004-03.pdf fig2_20231004-03.pdf fig3_20231004-03.pdf fig4_20231004-03.pdf fig5_20231004-03.pdf Suppl20231004-03.pdf
著者	Kemmotsu, Naoya\| Ninomiya, Kiichiro\| Kunimasa, Kei\| Ishino, Takamasa\| Nagasaki, Joji\| Otani, Yoshihiro\| Michiue, Hiroyuki\| Ichihara, Eiki\| Ohashi, Kadoaki\| Inoue, Takako\| Tamiya, Motohiro\| Sakai, Kazuko\| Ueda, Youki\| Dansako, Hiromichi\| Nishio, Kazuto\| Kiura, Katsuyuki\| Date, Isao\| Togashi, Yosuke\|
キーワード	cancer immunotherapy intracranial metastasis intracranial progression memory precursor effector T cell nonsmall-cell lung cancer
備考	This is the peer reviewed version of the following article: [Kemmotsu N, Ninomiya K, Kunimasa K, et al. Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies. Int J Cancer. 2024; 154(1): 169-179. doi:10.1002/ijc.34700], which has been published in final form at [https://doi.org/10.1002/ijc.34700]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext file will be available in Aug. 2024.\|
発行日	2023-08-23
出版物タイトル	International Journal of Cancer
巻	154巻
号	1号
出版者	Wiley
開始ページ	169
終了ページ	179
ISSN	0020-7136
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 UICC.
論文のバージョン	author
PubMed ID	37611176
DOI	10.1002/ijc.34700
Web of Science KeyUT	001069876600001
関連URL	isVersionOf https://doi.org/10.1002/ijc.34700

Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models

フルテキストURL	fulltext.pdf
著者	Kemmotsu, Naoya\| Zhu, Li\| Nagasaki, Joji\| Otani, Yoshihiro\| Ueda, Youki\| Dansako, Hiromichi\| Fang, Yue\| Date, Isao\| Togashi, Yosuke\|
キーワード	abscopal effect dendritic cell hydrogen peroxide radiosensitizer radiotherapy tumor-draining lymph node
発行日	2023-07-23
出版物タイトル	Cancer Science
巻	114巻
号	10号
出版者	Wiley
開始ページ	3848
終了ページ	3856
ISSN	1347-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37485636
DOI	10.1111/cas.15911
Web of Science KeyUT	001034657700001
関連URL	isVersionOf https://doi.org/10.1111/cas.15911

Activated CTLA-4-independent immunosuppression of Treg cells disturbs CTLA-4 blockade-mediated antitumor immunity

フルテキストURL	fulltext.pdf
著者	Watanabe, Tomofumi\| Ishino, Takamasa\| Ueda, Youki\| Nagasaki, Joji\| Sadahira, Takuya\| Dansako, Hiromichi\| Araki, Motoo\| Togashi, Yosuke\|
キーワード	antibody-dependent cell cytotoxicity cytotoxic T-lymphocyte-associated antigen 4 immune checkpoint inhibitors regulatory T cell renal cell carcinoma
発行日	2023-02-10
出版物タイトル	Cancer Science
出版者	Wiley
ISSN	1347-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	36762794
DOI	10.1111/cas.15756
Web of Science KeyUT	000940385500001
関連URL	isVersionOf https://doi.org/10.1111/cas.15756

Genetic Characterization of Hepatitis C Virus in Long-Term RNA Replication Using Li23 Cell Culture Systems

著者	Kato, Nobuyuki\| Sejima, Hiroe\| Ueda, Youki\| Mori, Kyoko\| Satoh, Shinya\| Dansako, Hiromichi\| Ikeda, Masanori\|
発行日	2014-03-13
出版物タイトル	PLOS ONE
巻	9巻
号	3号
資料タイプ	学術雑誌論文

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication

著者	Ueda, Youki\| Takeda, Midori\| Mori, Kyoko\| Dansako, Hiromichi\| Wakita, Takaji\| Kim, Hye-Sook\| Sato, Akira\| Wataya, Yusuke\| Ikeda, Masanori\| Kato, Nobuyuki\|
発行日	2013-08-30
出版物タイトル	PLOS ONE
巻	8巻
号	8号
資料タイプ	学術雑誌論文

The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly

著者	Dansako, Hiromichi\| Ueda, Youki\| Okumura, Nobuaki\| Satoh, Shinya\| Sugiyama, Masaya\| Mizokami, Masashi\| Ikeda, Masanori\| Kato, Nobuyuki\|
発行日	2015
出版物タイトル	The FEBS journal
資料タイプ	学術雑誌論文

Annexin A1 Negatively Regulates Viral RNA Replication of Hepatitis C Virus

JaLCDOI	10.18926/AMO/53335
フルテキストURL	69_2_71.pdf
著者	Hiramoto, Hiroki\| Dansako, Hiromichi\| Takeda, Midori\| Satoh, Shinya\| Wakita, Takaji\| Ikeda, Masanori\| Kato, Nobuyuki\|
抄録	Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies. In the present study, we found that the expression level of annexin A1 (ANXA1) in human hepatoma cell line Li23-derived D7 cells was remarkably lower than that in parental Li23 cells, whereas the susceptibility of D7 cells to HCV infection was much higher than that of Li23 cells. Therefore, we hypothesized that ANXA1 negatively regulates persistent HCV infection through the inhibition of viral RNA replication. The results revealed that HCV production was significantly inhibited without a concomitant reduction in the amount of lipid droplets in the D7 cells stably expressing exogenous ANXA1. Further, we demonstrated that ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes. These results suggest that ANXA1 would be a novel target for the development of anti-HCV strategies.
キーワード	HCV annexin A1 Li23 cell line Li23-derived D7 cells HCV-JFH-1
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-04
巻	69巻
号	2号
出版者	Okayama University Medical School
開始ページ	71
終了ページ	78
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25899628
Web of Science KeyUT	000353181700001

PML tumor suppressor protein is required for HCV production

著者	Kuroki, Misao\| Ariumi, Yasuo\| Hijikata, Makoto\| Ikeda, Masanori\| Dansako, Hiromichi\| Wakita, Takaji\| Shimotohno, Kunitada\| Kato, Nobuyuki\|
発行日	2013-01-11
出版物タイトル	Biochemical and Biophysical Research Communications
巻	430巻
号	2号
資料タイプ	学術雑誌論文

DNA 損傷センサーATMキナーゼとChk2はＣ型肝炎ウイルスのRNA複製に必要である

著者	有海康雄\| 黒木美沙緒\| 團迫浩方\| 阿部健一\| 池田正徳\| 脇田隆字\| 加藤宣之\|
発行日	2010-04-01
出版物タイトル	岡山医学会雑誌
巻	122巻
号	1号
資料タイプ	学術雑誌論文

Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element

著者	團迫浩方\|
発行日	2004-09-30
出版物タイトル
資料タイプ	学位論文

團迫 浩方