ID | 40129 |
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著者 |
Doi, Maho
Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyazaki, Ikuko
Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Nagamachi, Tomoko
Department of Pharmacy, Okayama University Hospital
Shinomiya, Kazuaki
Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Matsunaga, Hisashi
Department of Pharmacy, Okayama University Hospital
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Kawasaki, Hiromu
Department of Clinical Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Asanuma, Masato
Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Gomita, Yutaka
Shujitsu University School of Pharmacy
Kitamura, Yoshihisa
Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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抄録 | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
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キーワード | ACTH
imipramine
lithium
proliferation
Ki-67
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Amo Type | Original Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2010-08
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巻 | 64巻
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号 | 4号
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出版者 | Okayama University Medical School
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開始ページ | 219
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終了ページ | 223
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |